Recombinant Mouse Interferon-γ
Cat.No. : | Ifng-10M |
Product Overview : | Recombinant Mouse Interferon-γ produced inE. coliis a single non-glycosylated polypeptide chain containing 134 amino acids and having a molecular mass of 15.6 kDa. |
- Specification
- Gene Information
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Cat. No. : | Ifng-10M |
Description : | Interferon-gamma (IFN-γ, also known as Type II interferon or immune interferon) is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-β or the various IFN-α family proteins. Mature IFN-γ exists as noncovalently-linked homodimers. Human IFN-γ is highly species specific and is biologically active only in human and primate cells. IFN-γ was originally characterized based on its antiviral activities. The protein also exerts antiproliferative, immunoregulatory and proinflammatory activities and is thus important in host defense mechanisms. IFN-γ induces the production of cytokines, upregulates the expression of class I and II MHC antigens, Fc receptor and leukocyte adhesion molecules. It modulates macrophage effector functions, influences isotype switching and potentiates the secretion of immunoglobulins by B cells. IFN-γ also augments TH1 cell expansion and may be required for TH1 cell differentiation. |
Purity : | >95% by SDS-PAGE and HPLC analyses. |
Formulation : | Lyophilized from a 0.2mm filtered concentrated (1mg/ml) solution in PBS, pH 7.4. |
Specific Activity : | Fully biologically active when compared to standard. The specific activity as determined in a viral resistance assay is less than 0.1 ng/ml, corresponding to a specific activity of 1.0×107IU/ mg. |
Endotoxin : | Less than 1EU/mg of rmIFN-γ as determined by LAL method. |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤20°C. Further dilutions should be made in appropriate buffered solutions. |
Storage : | This lyophilized preparation is stable for several weeks at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles. |
Gene Name : | Ifng |
Synonyms : | Ifg; IFN-g; IFN-gamma; Immune Interferon; type II interferon; T cell interferon; MAF; IFNG; IFG; IFI; gamma interferon; Ifng; interferon gamma |
Gene ID : | 15978 |
mRNA Refseq : | NM_008337 |
Protein Refseq : | NP_032363 |
MIM : | 147570 |
UniProt ID : | Q6TDH0; P01580 |
Chromosome Location : | Chr 10: 117.84 - 117.85 Mb |
Pathway : | Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway; Natural killer cell mediated cytotoxicity; Regulation of autophagy; T cell receptor signaling pathway; TGF-beta signaling pathway; Type I diabetes mellitus |
Function : | cytokine activity; interferon-gamma receptor binding |
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◆ Lysates | ||
IFNG-1536RCL | Recombinant Rat IFNG cell lysate | +Inquiry |
IFNG-001HCL | Recombinant Human IFNG cell lysate | +Inquiry |
IFNG-1007FCL | Recombinant Ferret IFNG cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionIFNG plays an important role in tumor immunotherapy, which can activate the immune response of tumor cells, promote apoptosis of tumor cells and inhibit the proliferation of tumor cells.
The development of drugs for IFNG is currently in clinical trials, including monoclonal antibodies against IFNG receptors and inhibitors against IFNG signaling pathways.
Studies have shown that IFNG can inhibit the occurrence of muscle atrophy, but the specific mechanism is not clear.
In clinical practice, the expression level of IFNG can be measured to predict the progression and prognosis of the disease, and to guide the choice of treatment regimen.
Yes, there are other coding variants in the IFNG gene that may have different functions and expression patterns.
Such as nutritional status, inflammation levels, etc. Yes, the expression of IFNG is affected by environmental factors, such as nutritional status, inflammation level, etc.
Customer Reviews (3)
Write a reviewIt is analyzed by X-ray crystallography or other crystallization techniques and has good crystallization properties.
Easy to attach to the surface of cells or materials.
IFNG products have a complete range of specifications for experimental designs of different sizes and needs.
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