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Recombinant Mouse CXCL12 protein

Cat.No. : CXCL12-21M
Product Overview : Recombinant Mouse CXCL12 beta protein was expressed in Escherichia coli.
  • Specification
  • Gene Information
  • Related Products
Description : CXCL12 also known as SDF-1 is belonging to the CXC chemokine family. Murine CXCL12 is expressed as two isoforms that differ only in the C-terminal tail. Both SDF-1 isoforms undergo proteolytic processing of the first two N-terminal amino acids. In all SDF-1 isoforms, SDF-1β is the canonical sequence. It has the complete amino acids in the C-terminal tail. On the cell surface, the receptor for this chemokine is CXCR4 and syndecan4. CXCL12 is strongly chemotactic for T-lymphocytes, monocytes, but not neutrophils. SDF-1 is highly conserved between species, murine CXCL12β shares approximately 92 % amino acid sequence identity with human CXCL12β.
Source : E.coli
Species : Mouse
Form : Lyophilized from a 0.2μm filtered concentrated solution in 20 mM PB, pH 7.4, 150 mM NaCl.
Bio-activity : Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood monocytes is in a concentration range of 50-100 ng/ml.
Molecular Mass : Approximately 8.5 kDa, a single non-glycosylated polypeptide chain containing 72 amino acids.
Protein length : 72
AA Sequence : KPVSLSYRCPCRFFESHIARANVKH LKILNTPNCALQIVARLKNNNRQVC IDPKLKWIQEYLEKALNKRLKM
Endotoxin : Less than 1 EU/μg of rMuSDF-1β/CXCL12βas determined by LAL method.
Purity : >97% by SDS-PAGE and HPLC analysis.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 centigrade as supplied. 1 month, 2 to 8 centigrade under sterile conditions after reconstitution. 3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
Reconstitution : We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤-20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name : CXCL12
Official Symbol : CXCL12
Synonyms : CXCL12; chemokine (C-X-C motif) ligand 12; stromal cell-derived factor 1; C-X-C motif chemokine 12; pre-B cell growth-stimulating factor; pre-B-cell growth-stimulating factor; thymic lymphoma cell-stimulating factor; 12-O-tetradecanoylphorbol 13-acetate repressed protein 1; Pbsf; Sdf1; Tlsf; Sdf1a; Sdf1b; Tlsfa; Tlsfb; Tpar1; Scyb12; AI174028;
Gene ID : 20315
mRNA Refseq : NM_001012477
Protein Refseq : NP_001012495
UniProt ID : P40224

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How are researchers using CXCL12 in neurodegenerative disease research? 08/27/2022

CXCL12 is being investigated for its role in neuroprotection and neuroregeneration in conditions like Alzheimer's and Parkinson's disease.

Are there diagnostic tests that measure CXCL12 levels in patients? 12/19/2021

Yes, ELISA and other assays can be used to measure CXCL12 levels, aiding in the diagnosis and monitoring of certain diseases.

Can CXCL12 be used as a biomarker for specific diseases? 02/03/2021

CXCL12 levels can serve as a biomarker for various diseases, such as HIV, cancer, and inflammatory disorders.

How is CXCL12 being researched for cardiovascular therapies? 06/16/2019

Scientists are exploring the potential of CXCL12-based therapies to promote vascular repair and treat heart diseases.

Can CXCL12-based therapies help in spinal cord injury treatment? 04/02/2019

Researchers are studying CXCL12-based treatments to promote nerve regeneration and functional recovery after spinal cord injuries.

Customer Reviews (3)

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Reviews
06/15/2022

    The CXCL12 protein is of exceptional quality, making it an ideal candidate to fulfill my experimental requirements.

    01/08/2022

      The manufacturer's commitment to providing excellent technical support is truly commendable, as they have proven to be readily available to assist in resolving any concerns or challenges I encountered while working with the protein.

      04/26/2021

        Its purity and integrity have consistently delivered reliable and robust results in my research.

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