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Recombinant Murine Chemokine (C-X-C Motif) Ligand 12(SDF1b)

Cat. No.: CXCL12-21M
Production Description: SDF-1α and SDF-1β, members of the chemokine α subfamily that lack the ELR domain, were initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. These proteins were subsequently also cloned from a human stromal cell line as cytokines that supported the proliferation of a stromal cell-dependent pre-B-cell line. SDF-1α and SDF-1β cDNAs encode precursor proteins of 89 and 93 amino acid residues, respectively. Both SDF-1α and SDF-1β are encoded by a single gene and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy-terminus of SDF-1β and absent from SDF-1α.
Source: Escherichia coli.
Molecular Weight: 8.5 kDa, a single, non-glycosylated polypeptide chain containing 72 amino acids.
Quantity: 2ug/10ug/1000μg
Purity: >97% by SDS-PAGE and HPLC analyses.
Biological Activity: Fully biologically active when compared to standard. Determined by its ability to chemoattract human monocytes using a concentration range of 50.0-100.0 ng/ml.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation: Lyophilized from a 0.2μm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl.
Endotoxin: Less than 1EU/μg of rMu SDF-1 beta /CXCL12 as determined by LAL method.
AA Sequence: KPVSLSYRCP CRFFESHIAR ANVKHLKILN TPNCALQIVA RLKNNNRQVC IDPKLKWIQE YLEKALNKRL KM
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at <-20°C. Further dilutions should be made in appropriate buffered solutions.
Storage: This lyophilized preparation is stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8°C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20°C to -70°C. Avoid repeated freeze/thaw cycles.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Pathways: Axon guidance; Cytokine-cytokine receptor interaction; Leukocyte transendothelial migration.
Gene Name: Cxcl12 chemokine (C-X-C motif) ligand 12 [ Mus musculus ]
Synonyms: CXCL12; PBSF; SCYB12; SDF-1a; SDF-1b; SDF1; SDF1A; SDF1B; TLSF-a; TLSF-b; TPAR1; chemokine (C-X-C motif) ligand 12; Sdf1; TLSF; SDF-1; Sdf1a; Sdf1b; TPAR1; Scyb12; AI174028; PBSF/SDF-1; Cxcl12; stromal cell derived factor 1; stromal cell derived factor 1;OTTMUSP00000026112; OTTMUSP00000026113; OTTMUSP00000026114; pre-B-cell growth-stimulating factor; OTTHUMP00000019491; hIRH; C-X-C motif chemokine 12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); stromal cell-derived factor 1; stromal cell-derived factor 1 delta; stromal cell-derived factor 1 gamma; stromal cell-derived factor 1a.
Gene ID: 20315
mRNA Refseq: NM_001012477
Protein Refseq: NP_001012495
UniProt ID: P40224
Chromosome Location: 6 F1; 6 53.0 cM
Function: Chemokine activity; cytokine activity; growth factor activity.

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