Native Human Fibronectin 1

• Cat.No.: FN1-701H
• Product Overview: Native Human FN1 was purified from human plasma.

Specification

• Cat. No.: FN1-701H
• Description: This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
• Source: Human plasma
• Molecular Mass: 550 kDa
• Formulation: Lyophilized from 20 mM Hepes, 150 mM NaCl, pH 7.4
• Purity: >95% by SDS-PAGE
• ActivityDetermination: N/A
• Localization: plasma, 0.3 mg/ml; extracellular matrix
• Mode of action: mediates cell attachment to extracellular matrix
• Structure: heterodimer
• Storage: 4oC
• OfficialSymbol: FN1

Gene Information

• Gene Name: FN1 fibronectin 1 [ Homo sapiens ]
• Synonyms: FN1; fibronectin 1; FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; fibronectin; cold-insoluble globulin; migration-stimulating factor
• Gene ID: 2335
• mRNA Refseq: NM_002026
• Protein Refseq: NP_002017
• MIM: 135600
• UniProt ID: P02751
• Chromosome Location: 2q34
• Pathway: ECM-receptor interaction; Focal adhesion; Pathways in cancer; Regulation of actin cytoskeleton; Hemostasis; Integrin cell surface interactions; Signaling in Immune system
• Function: collagen binding; extracellular matrix structural constituent; heparin binding