Native Human Fibronectin 1


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Native Human Fibronectin 1

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Cat. No. : FN1-701H
Product Overview : Native Human FN1 was purified from human plasma.
Description : This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
Source : Human plasma
Molecular Mass : 550 kDa
Formulation : Lyophilized from 20 mM Hepes, 150 mM NaCl, pH 7.4
Purity : >95% by SDS-PAGE
ActivityDetermination : N/A
Localization : plasma, 0.3 mg/ml; extracellular matrix
Mode of action : mediates cell attachment to extracellular matrix
Structure : heterodimer
Storage : 4oC
OfficialSymbol : FN1
PDB rendering basedon 1e88. :

Gene Name : FN1 fibronectin 1 [ Homo sapiens ]
Synonyms : FN1; fibronectin 1; FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2; fibronectin; cold-insoluble globulin; migration-stimulating factor
Gene ID : 2335
mRNA Refseq : NM_002026
Protein Refseq : NP_002017
MIM : 135600
UniProt ID : P02751
Chromosome Location : 2q34
Pathway : ECM-receptor interaction; Focal adhesion; Pathways in cancer; Regulation of actin cytoskeleton; Hemostasis; Integrin cell surface interactions; Signaling in Immune system
Function : collagen binding; extracellular matrix structural constituent; heparin binding

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