Recombinant Human PPIC, His-tagged

• Cat.No.: PPIC-7969H
• Product Overview: Recombinant Human Cyclophilin C/CYPC is produced by our E. coli expression system. The target protein is expressed with sequence (Trp131Asp182) of Human CYPC fused with a His tag at the Cterminus.

Specification

• Description: Cyclophilin C is an enzyme (EC 5.2.1.8) found in both prokaryotes and eukaryotes that interconverts the cis and trans isomers of peptide bonds with the amino acid proline. Proline has an unusually conformationally restrained peptide bond due to its cyclic structure with its side chain bonded to its secondary amine nitrogen. Most amino acids have a strong energetic preference for the trans peptide bond conformation due to steric hindrance, but prolines unusual structure stabilizes the cis form so that both isomers are populated under biologically relevant conditions. Proteins with prolyl isomerase activity include cyclophilin, FKBPs, and parvulin, although larger proteins can also contain prolyl isomerase domains.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Supplied as a 0.2 μM filtered solution of 20mM PB, 150mM NaCl, 10% Glycerol, pH 7.4
• AA Sequence: MSDKIIHLTD DSFDTDVLKA DGAILVDFWA EWCGPCKMIA PILDEIADEY QGKLTVAKLN IDQNPGTAP KYGIRGIPTL LLFKNGEVAA TKVGALSKGQ LKEFLDANLA GSGSGHMHHH H HHSSGLVP RGSGMKETAA AKFERQHMDS PDLGTDDDDK AMAKRGPSVT AKVFFDVRIG DK DVGRIVI GLFGKVVPKT VENFVALATG EKGYGYKGSK FHRVIKDFMI QGGDITTGDG TGG VSIYGE TFPDENFKLK
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Notes: For research use only.
• Storage: Store at less than 20°C. stable for 6 months after receipt.Please minimize freezethaw cycles.

Gene Information

• Gene Name: PPIC peptidylprolyl isomerase C (cyclophilin C) [ Homo sapiens ]
• Official Symbol: PPIC
• Synonyms: PPIC; peptidylprolyl isomerase C (cyclophilin C); CYPC; PPIase C; cyclophilin C; parvulin; peptidyl-prolyl cis-trans isomerase C; rotamase C; HGNC:9256
• Gene ID: 5480
• mRNA Refseq: NM_000943.4
• Protein Refseq: NP_000934.1
• MIM: 123842
• UniProt ID: P45877
• Chromosome Location: 5q23.2
• Function: cyclosporin A binding; peptidyl-prolyl cis-trans isomerase activity; unfolded protein binding