Cat.No.:	ELANE-8236H
Product Overview:	Human Neutrophil Elastase (ELA-2) was purified from Human Neutrophils.
Description:	Human Neutrophils, also known as neutrophilic polymorphonuclear leukocytes, are the major class of white blood cell in human peripheral blood. Human Neutrophil(s), have a multilobed nucleus and neutrophilic granules. Neutrophil(s) are phagocytes and have an important role in engulfing and killing extracellular pathogens.
Source:	Human Neutrophils
Species:	Human
Form:	Lyophilized from 50 mM acetate buffer
Purity:	>95% by SDS-PAGE
Unit Definition:	One unit will hydrolyze one micromole of Methoxy succinyl-alanine-alanine-proline-valine-p-nitroanilide per minute at 37 °C and pH 7.5.
Stability:	2 years

Gene Name:	ELANE elastase, neutrophil expressed [ Homo sapiens ]
Official Symbol:	ELANE
Synonyms:	ELANE; elastase, neutrophil expressed; ELA2, elastase 2, neutrophil; neutrophil elastase; HLE; HNE; leukocyte elastase; medullasin; NE; elastase-2; PMN elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow se
Gene ID:	1991
mRNA Refseq:	NM_001972
Protein Refseq:	NP_001963
MIM:	130130
UniProt ID:	P08246
Chromosome Location:	19p13.3
Pathway:	Activation of Matrix Metalloproteinases, organism-specific biosystem; C-MYB transcription factor network, organism-specific biosystem; Degradation of the extracellular matrix, organism-specific biosystem; Extracellular matrix organization, organism-specific biosystem; Systemic lupus erythematosus, organism-specific biosystem; Systemic lupus erythematosus, conserved biosystem; Transcriptional misregulation in cancer, organism-specific biosystem;
Function:	bacterial cell surface binding; cytokine binding; endopeptidase activity; heparin binding; peptidase activity; protease binding; protein binding; serine-type endopeptidase activity;

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