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Recombinant Mouse Fgf17

Cat.No.: Fgf17-8333M
Product Overview: Recombinant Mouse Fgf17 was expressed in E. coli.
Description: Fibroblast growth factor-8 (FGF-8), also known as AIGF and HBGF, is a heparin binding growth factor belonging to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. Alternate splicing of FGF-8 mRNA creates eight secreted isoforms (a-h) in mice and four (a, b, e and f) in humans. FGF-8a expands the midbrain in transgenic mice, while FGF-8b transforms the midbrain into cerebellum. FGF-8 activates the "c" splice forms of receptors FGF R2, FGF R3 and FGF R4, with differential activity among the FGF-8 isoforms. Overexpression of FGF-8 has been shown to increase tumor growth and angiogenesis. FGF-8b shows the strongest receptor affinity and oncogenic transforming capacity, although isoforms a and e have been found in human tumors. The adult expression of FGF-8 is restricted to testes and ovaries.
Source: E. coli
Species: Mouse
Form: This recombinant protein was lyophilized from a 0.2 μm filtered solution in MOPS, EDTA, Dithiothreitol (DTT), and sodium sulphate (Na2SO4).
Molecular Mass: The predicted molecular weight of Recombinant Mouse FGF-8b is Mr 22.5 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 23 kDa.
AA Sequence: mqvtvqssp nftqhvreqs lvtdqlsrrl irtyqlysrt sgkhvqvlan krinamaedg dpfaklivet dtfgsrvrvr gaetglyicm nkkgkliaks ngkgkdcvft eivlennyta lqnakyegwy maftrkgrpr kgsktrqhqr evhfmkrlpr ghhtteqslr feflnyppft rslrgsqrtw apepr
Endotoxin: <1.0 eu/μg as determined by the lal>
Purity: >97% by SDS-PAGE and analyzed by silver stain.
Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Gene Name: Fgf17 fibroblast growth factor 17 [ Mus musculus ]
Official Symbol: Fgf17
Synonyms: FGF17; fibroblast growth factor 17; FGF-17;
Gene ID: 14171
mRNA Refseq: NM_008004
Protein Refseq: NP_032030
Pathway: Downstream signaling of activated FGFR, organism-specific biosystem; ESC Pluripotency Pathways, organism-specific biosystem; FGFR ligand binding and activation, organism-specific biosystem; FGFR1 ligand binding and activation, organism-specific biosystem; FGFR1c ligand binding and activation, organism-specific biosystem; FGFR2 ligand binding and activation, organism-specific biosystem; FGFR2c ligand binding and activation, organism-specific biosystem;
Function: growth factor activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding;

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