Recombinant Human OSCAR, His-tagged

• Cat.No.: OSCAR-7618H
• Product Overview: Recombinant human OSCAR protein, fused to His-tag at N-terminus, was expressed in E.coli.

Specification

• Description: Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. OSCAR is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.?
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea, 10% glycerol
• Molecular Mass: 31kDa (291aa)
• Protein length: 19-286aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSDITPSVA IIVPPASYHP KPWLGAQPAT VVTPGVNVTL RCRAPQPAWR FGLFKPGEIA PLLFRDVSSE LAEFFLEEVT PAQGGIYRCC YRRPDWGPGV WSQPSDVLEL LVTEELPRPS LVALPGPVVG PGANVSLRCA GRLRNMSFVL YREGVAAPLQ YRHSAQPWAD FTLLGARAPG TYSCYYHTPS APYVLSQRSE VLVISWEGEG PEARPASSAP GMQAPGPPPS DPGAQAPSLS SFRPRGLVLQ PLLPQTQDSW DPAPPPSDPG V
• Purity: >85% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term. For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
• Concentration: 0.25 mg/ml

Gene Information

• Gene Name: OSCAR osteoclast associated, immunoglobulin-like receptor [ Homo sapiens ]
• Official Symbol: OSCAR
• Synonyms: OSCAR; osteoclast associated, immunoglobulin-like receptor; osteoclast-associated immunoglobulin-like receptor; PIgR-3; hOSCAR; poly-Ig receptor 3; osteoclast-associated receptor; polymeric immunoglobulin receptor 3; osteoclast associated receptor OSCAR-S1; osteoclast associated receptor OSCAR-S2; PIGR3; MGC33613
• Gene ID: 126014
• mRNA Refseq: NM_206818
• Protein Refseq: NP_996554
• MIM: 606862
• UniProt ID: Q8IYS5
• Chromosome Location: 19q13.42
• Pathway: Osteoclast differentiation, organism-specific biosystem; Osteoclast differentiation, conserved biosystem
• Function: receptor activity