Recombinant Human TNFAIP8, His-tagged

• Cat.No.: TNFAIP8-7639H
• Product Overview: Recombinant human TNFAIP8 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Specification

• Description: TNFAIP8 belongs to the TNFAIP8 family. This protein acts as a negative mediator of apoptosis and may play a role in tumor progression. It suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
• Molecular Mass: 25kDa (221aa)
• Protein length: 1-198aa
• AA Sequence: MGSSHHHHHH SSGLVPRGSH MGSMHSEAEE SKEVATDVFN SKNLAVQAQK KILGKMVSKS IATTLIDDTS SEVLDELYRV TREYTQNKKE AEKIIKNLIK TVIKLAILYR NNQFNQDELA LMEKFKKKVH QLAMTVVSFH QVDYTFDRNV LSRLLNECRE MLHQIIQRHL TAKSHGRVNN VFDHFSDCEF LAALYNPFGN FKPHLQKLCD GINKMLDEEN I
• Purity: >90% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at 4°C short term. For long term storage, aliquot and store at -20°C or -70°C.Avoid repeated freezing and thawing cycles.
• Concentration: 0.25mg/ml?

Gene Information

• Gene Name: TNFAIP8 tumor necrosis factor, alpha-induced protein 8 [ Homo sapiens ]
• Official Symbol: TNFAIP8
• Synonyms: TNFAIP8; tumor necrosis factor, alpha-induced protein 8; tumor necrosis factor alpha-induced protein 8; GG2 1; MDC 3.13; SCC S2; NDED; TNF-induced protein GG2-1; TNF alpha-induced protein 8; NF-kappa-B-inducible DED-containing protein; head and neck tumor and metastasis-related protein; GG2-1; SCCS2; SCC-S2; MDC-3.13
• Gene ID: 25816
• mRNA Refseq: NM_014350
• Protein Refseq: NP_055165
• MIM: 612111
• UniProt ID: O95379
• Chromosome Location: 5q23.1
• Function: cysteine-type endopeptidase inhibitor activity involved in apoptotic process