Active Recombinant Human ADAMTS4, His-tagged

• Cat.No.: ADAMTS4-534H
• Product Overview: Recombinant Human ADAMTS4 (Phe213-Cys685) fused with a C­terminal 10­His tag, was expressed in CHO Cells.

Specification

• Cat. No.: ADAMTS4-534H
• Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
• Source: CHO Cells
• Molecular Mass: 53 kDa
• Predicted N terminal: Phe213
• Formulation: Supplied as a 0.2 µm filtered solution in Sodium Acetate, CaCl2 and NaCl.
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Activity: Measured by its ability to cleave Recombinant Human Aggrecan G1-IGD-G2 Domains.
• EndotoxinLevel: <1.0 EU per 1 μg of the protein by the LAL method.
• Storage: 6 months from date of receipt, ­20 to ­70 °C as supplied. Avoid repeated freeze­thaw cycles.
• OfficialSymbol: ADAMTS4

Gene Information

• Gene Name: ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 [ Homo sapiens ]
• Synonyms: ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688; ADAMTS4; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; EC 3.4.24.82
• Gene ID: 9507
• mRNA Refseq: NM_005099
• Protein Refseq: NP_005090
• MIM: 603876
• UniProt ID: O75173
• Chromosome Location: 1q21-q23
• Pathway: Endochondral Ossification
• Function: metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protease binding; protein binding; zinc ion binding

Reviews

09/05/2021

Professional personnel to provide after-sales service, experimental results are guaranteed.

10/21/2020

High protein concentration, good quality, worth buying.

08/21/2019

The technicians were very professional and suggested improvements to my experimental program, which allowed the experiment to go smoothly.

Q&As

What is ADAMTS4 secreted by?

ADAMTS4 is an inflammatory factor secreted by macrophages.

What is the relationship between ADAMTS4 and IL-1β?

IL-1β can induce ADAMTS4 expression.

Where is ADAMTS4 expressed?

ADAMTS4 is expressed in the heart, joint tissues, lungs, and other sites.

What is the biological function of ADAMTS4?

ADAMTS4 is involved in the degradation of multifunctional proteoglycans in the vascular wall.

What diseases is ADAMTS4 used to study?

ADAMTS4 could be used in research into diseases such as colorectal and gastric cancer.