Recombinant Human ADAMTS4, His-tagged

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Recombinant Human ADAMTS4, His-tagged

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Cat. No. : ADAMTS4-534H
Product Overview : Recombinant Human ADAMTS4 (Phe213-Cys685) fused with a C­terminal 10­His tag, was expressed in CHO Cells.
Description : This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.
Source : CHO Cells
Molecular Mass : 53 kDa
Predicted N terminal : Phe213
Formulation : Supplied as a 0.2 µm filtered solution in Sodium Acetate, CaCl2 and NaCl.
Purity : >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Activity : Measured by its ability to cleave Recombinant Human Aggrecan G1-IGD-G2 Domains.
EndotoxinLevel : <1.0 EU per 1 μg of the protein by the LAL method.
Storage : 6 months from date of receipt, ­20 to ­70 °C as supplied. Avoid repeated freeze­thaw cycles.
OfficialSymbol : ADAMTS4
Available structures :

Gene Name : ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 [ Homo sapiens ]
Synonyms : ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; ADAMTS-2; ADAMTS-4; KIAA0688; ADAMTS4; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4; EC 3.4.24.82
Gene ID : 9507
mRNA Refseq : NM_005099
Protein Refseq : NP_005090
MIM : 603876
UniProt ID : O75173
Chromosome Location : 1q21-q23
Pathway : Endochondral Ossification
Function : metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protease binding; protein binding; zinc ion binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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