Native Bovine HMGB1

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Native Bovine HMGB1

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Cat.No. : HMGB1-8447B
Product Overview : Native Bovine HMGB1 was purified from Calf Thymus.
Description : High mobility group 1 (HMG1) is a 26 kDa highly conserved non-sequence-specific DNA-binding nuclear protein. Mammalian HMG1 has two homologous DNA-binding domains HMG boxes, A and B (each of 80–90 amino-acid residues), linked by a short basic region to an acidic C-terminal domain containing 30 consecutive Asp and Glu residues. HMG1 has been implicated in a number of fundamental biological processes including transcription, replication and recombination, in which it plays a role in manipulating DNA structure by bending, looping, compaction or unwinding, or by directly contacting with distinct cellular proteins . HMG-1 can act as a repressor, by interacting with TBP to block pre-initiation complex formation or as an activator, by facilitating the binding of various transcription factors to their cognate DNA sequences. Most recently, it was discovered that HMG-1 is a late mediator of delayed endotoxin lethality by activating downstream cytokine release.
Source : Calf Thymus
Species : Bovine
Tag : N/A
Form : 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Bio-activity : 1 unit equals 1 ng of purified protein. 10-100 units are required for a gel mobility shift assay in a 20μl reaction to super-shift TBP-DNA complex, 50-500 units are required for a reconstituted transcription assay and 100 units are sufficient for a protein-protein interaction assay.
AA Sequence : MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK SKKKKEEEED EEDEEDEEEE EDEEDEEEEE DDDDE
Purity : >95% as determined by SDS-PAGE
Storage : -80 °C
Concentration : 900 μg/ml
Shipping : Dry Ice
Gene Name : HMGB1 high mobility group box 1 [ Bos taurus ]
Official Symbol : HMGB1
Synonyms : HMGB1; high mobility group box 1; high mobility group protein B1; HMG-1; high mobility group protein 1
Gene ID : 282691
mRNA Refseq : NM_176612
Protein Refseq : NP_788785
UniProt ID : 10103
Chromosome Location : chromosome: 12
Pathway : Androgen Receptor Signaling Pathway, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem
Function : DNA binding, bending; chemoattractant activity; damaged DNA binding; double-stranded DNA binding

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