Recombinant Human FOSL1, His-tagged FOSL1-8500H

Recombinant Human FOSL1, His-tagged

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Recombinant Human FOSL1, His-tagged

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Cat.No. : FOSL1-8500H
Product Overview : Recombinant Human FOSL1, fused with His tag, was expressed in Sf21 Cells.
Description : The fos-related antigen 1 (Fra-1, or FosL1: Fos-like antigen 1) is a member of the Fos onco-protein family and a component of AP-1 transcription factor. Similar to other members of the family, Fra-1 contains a leucine zipper domain and a highly conserved C-terminal region. Transcription of Fra-1 gene is regulated by multiple cis-elements and 12-O-tetradecanoylphorbol-13-acetate (TPA). Fra-1 expression is associated with proliferation and invasiveness of breast cancer cells and other cancer cells.
Source : Sf21 Cells
Species : Human
Tag : His
Form : 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Bio-activity : 1 unit equals 1 ng of purified protein. 20-200ng is sufficient for an in vitro transcription assay and 100ng is sufficient for a protein-protein interaction assay.
AA Sequence : MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L
Purity : >95% as determined by SDS-PAGE
Storage : -80 °C
Concentration : 350 μg/ml
Shipping : Dry Ice
Gene Name : FOSL1 FOS-like antigen 1 [ Homo sapiens ]
Official Symbol : FOSL1
Synonyms : FOSL1; FOS-like antigen 1; fos-related antigen 1; fra 1; FOS-like antigen-1; FRA; FRA1; fra-1;
Gene ID : 8061
mRNA Refseq : NM_005438
Protein Refseq : NP_005429
MIM : 136515
UniProt ID : P15407
Chromosome Location : 11q13
Pathway : Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Osteoclast differentiation, organism-specific biosystem;
Function : protein binding; protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

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