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Active Recombinant Human FOSL1, His-tagged

Cat.No. : FOSL1-8500H
Product Overview : Recombinant Human FOSL1, fused with His tag, was expressed in Sf21 Cells.
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  • Gene Information
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Description : The fos-related antigen 1 (Fra-1, or FosL1: Fos-like antigen 1) is a member of the Fos onco-protein family and a component of AP-1 transcription factor. Similar to other members of the family, Fra-1 contains a leucine zipper domain and a highly conserved C-terminal region. Transcription of Fra-1 gene is regulated by multiple cis-elements and 12-O-tetradecanoylphorbol-13-acetate (TPA). Fra-1 expression is associated with proliferation and invasiveness of breast cancer cells and other cancer cells.
Source : Sf21 Cells
Species : Human
Tag : His
Form : 20 mM Tris-Cl, pH 7.9, 20% Glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA
Bio-activity : 1 unit equals 1 ng of purified protein. 20-200ng is sufficient for an in vitro transcription assay and 100ng is sufficient for a protein-protein interaction assay.
AA Sequence : MFRDFGEPGP SSGNGGGYGG PAQPPAAAQA AQQKFHLVPS INTMSGSQEL QWMVQPHFLG PSSYPRPLTY PQYSPPQPRP GVIRALGPPP GVRRRPCEQI SPEEEERRRV RRERNKLAAA KCRNRRKELT DFLQAETDKL EDEKSGLQRE IEELQKQKER LELVLEAHRP ICKIPEGAKE GDTGSTSGTS SPPAPCRPVP CISLSPGPVL EPEALHTPTL MTTPSLTPFT PSLVFTYPST PEPCASAHRK SSSSSGDPSS DPLGSPTLLA L
Purity : >95% as determined by SDS-PAGE
Storage : -80 °C
Concentration : 350 μg/ml
Shipping : Dry Ice
Gene Name : FOSL1 FOS-like antigen 1 [ Homo sapiens ]
Official Symbol : FOSL1
Synonyms : FOSL1; FOS-like antigen 1; fos-related antigen 1; fra 1; FOS-like antigen-1; FRA; FRA1; fra-1;
Gene ID : 8061
mRNA Refseq : NM_005438
Protein Refseq : NP_005429
MIM : 136515
UniProt ID : P15407
Chromosome Location : 11q13
Pathway : Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Calcium signaling in the CD4+ TCR pathway, organism-specific biosystem; DNA damage response (only ATM dependent), organism-specific biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; Osteoclast differentiation, organism-specific biosystem;
Function : protein binding; protein dimerization activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any ongoing studies investigating the role of FOSL1 in combination with other targeted therapies? 02/07/2022

Yes, preclinical studies and early-phase clinical trials are exploring the potential synergistic effects of combining FOSL1 inhibitors with other targeted therapies to enhance treatment efficacy.

How does the expression of FOSL1 correlate with patient survival in different cancers? 10/06/2021

High expression levels of FOSL1 have been associated with poor prognosis and shorter overall survival in various cancer patients.

How does the regulation of FOSL1 impact tumor microenvironment and metastasis? 05/06/2021

FOSL1 regulates the tumor microenvironment by promoting angiogenesis, immune evasion, and metastasis, thus contributing to cancer progression and spread.

What are the potential side effects of targeting FOSL1 in cancer treatment? 02/18/2017

Although the specific side effects may vary, common adverse effects of FOSL1-targeted therapies may include gastrointestinal disturbances, fatigue, and immunological reactions.

How does the dysregulation of FOSL1 contribute to tumorigenesis? 08/05/2016

Dysregulated FOSL1 expression can disrupt cellular homeostasis, leading to uncontrolled cell proliferation, evasion of cell death, and genomic instability, all of which contribute to tumorigenesis.

Customer Reviews (3)

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Reviews
09/22/2022

    This reliable supply chain management assures that I have uninterrupted access to the protein, allowing me to plan and conduct my experiments without concern for availability issues.

    05/27/2019

      They ensure a reliable and consistent supply of FOSL1 protein, minimizing any potential disruptions in my experimental workflow.

      07/07/2016

        They ensure a reliable and consistent supply of FOSL1 protein, minimizing any potential disruptions in my experimental workflow.

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