Native Bovine MFGE8, Fluoresence-labeled

• Cat.No.: MFGE8-8518B
• Product Overview: Native Bovine Lactadherin is purified from un-pasteurized bovine milk.

Specification

• Description: Lactadherin is a widely distributed glycoprotein (~ 50 kDa), which was originally characterized due to its association with milk fat/lipid globule membranes. Synonymous names are PAS-6/7, bovine-associated mucoprotein, BA-46, P47, and MFG-E8. Structural hallmarks of lactadherin are the presence of two epidermal growth factor (EGF) homology domains (with an RGD peptide motif in the second EGF domain), and two C domains sharing homology with the discoidin family of lectin domains including the phospholipid-binding domains of blood clotting factors V and VIII. Lactadherin shows preferential binding to phosphatidylserine (L-form) in a calcium independent manner. Purified lactadherin functions as an anticoagulant by blocking phosphatidylserine-containing membrane sites for blood coagulation proteins. Fluoresence-labeled lactadherin functions as a sensitive probe for exposed phosphatidylserine on nucleated cells and on stimulated platelets. Lactadherin will bind to membranes that have phosphatidylserine content below the threshold for annexin V binding.
• Source: Bovine
• Species: Bovine
• Form: 70 mM Sodium Phosphate, pH 7.0
• Molecular Mass: 52 kDa and 47 kDa (glycosylation variants, PAS-6 and PAS-7 respectively)
• Purity: >95% by SDS-PAGE (both)
• Storage: -70℃

Gene Information

• Gene Name: MFGE8 milk fat globule-EGF factor 8 protein [ Bos taurus ]
• Official Symbol: MFGE8
• Synonyms: MFGE8; BP47; MFG-E8; MFGM; MGP57/53; PAS-6/PAS-7 glycoprotein; SED1; components 15/16; lactadherin; sperm surface protein SP47
• Gene ID: 281913
• mRNA Refseq: NM_176610.1
• Protein Refseq: NP_788783.1
• UniProt ID: Q95114