Recombinant Human MFGE8 Protein (Met1-Lys239, Trp137-Cys387), C-His tagged

• Cat.No.: MFGE8-4542H
• Product Overview: Recombinant human MFGE8 (Met1-Lys239, Trp137-Cys387) fused with the C-terminal His tag was expressed in E. coli.

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 54.9 kDa
• Protein length: Met1-Lys239, Trp137-Cys387
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: MFGE8 milk fat globule-EGF factor 8 protein [ Homo sapiens (human) ]
• Official Symbol: MFGE8
• Synonyms: MFGE8; milk fat globule-EGF factor 8 protein; SPAG10, sperm associated antigen 10; lactadherin; BA46; EDIL1; hP47; HsT19888; MFG E8; OAcGD3S; SED1; sperm surface protein hP47; medin; sperm associated antigen 10; breast epithelial antigen BA46; O-acetyl disialoganglioside synthase; HMFG; MFGM; MFG-E8; SPAG10
• Gene ID: 4240
• mRNA Refseq: NM_001114614
• Protein Refseq: NP_001108086
• MIM: 602281
• UniProt ID: Q08431

Reviews

08/08/2022

It has high application effect and safety in clinical treatment.

10/08/2021

MFGE8 has a high resolution in Western blots, which can distinguish similar protein molecular weights.

11/09/2020

Good stability and activity retention during long-term storage.

Q&As

Is there a relationship between MFGE8's structure and function?

The structure of MFGE8 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.

Does MFGE8 interact with other proteins?

MFGE8 can interact with a variety of other proteins, including Caspase-3, Caspase-8, EGFR, etc. These interactions enable it to regulate processes such as apoptosis, signal transduction, and cell adhesion.

What will future research on MFGE8 focus on?

Future studies of MFGE8 may focus on the following aspects: its structure-function relationship, mechanisms of interaction with other proteins, regulatory mechanisms in cells, and potential therapeutic applications. At the same time, the study of MFGE8's interaction with specific signal transduction pathways and its regulatory effect on cell growth and differentiation will also become one of the future research priorities.

What are the treatment strategies for MFGE8?

Therapeutic strategies for MFGE8 may include regulating its expression level, inhibiting its interaction with other proteins, and promoting or inhibiting its function. These methods may have potential applications in the treatment of cancer, neurodegenerative diseases, and autoimmune diseases.

Does MFGE8 have a role in neurodegenerative diseases?

In neurodegenerative diseases, MFGE8 may influence the survival and death processes of neurons by regulating apoptosis and signal transduction. It could be a potential target for the treatment of neurodegenerative diseases.

What factors should be considered in drug development for MFGE8?

Drug development against MFGE8 needs to consider its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.