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Recombinant Human Bone Morphogenetic Protein 5

Cat.No. : BMP5-26H
Product Overview : Recombinant Human BMP5 was expressed in NSO Cells.
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  • Gene Information
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Cat. No. : BMP5-26H
Description : This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors.
Source : Mammalian cells
Molecular Mass : The predicted molecular weight of Recombinant Human BMP-5 is Mr 19 kDa (monomer) with the extra 34 amino acid residues from BMP-2, and 16 kDa (monomer) on mature BMP-5. However, the actual molecular weight as observed by migration on SDS Page is Mr 20 and 25 kDa under reducing conditions.
State of Matter : Lyophilized
Formulation : This recombinant protein was lyophilized from a 0.2 μm filtered solution in 35% acetonitrile (CH3CN) and 0.1% trifluoroacetic acid (TFA) with trehalose.
Purity : >95% by SDS-PAGE and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method
Amino Acid Sequence : (Human BMP-2 propeptide; Ser249-Arg282) nqnrnkss shqdssrmss vgdyntseqk qackkhelyv sfrdlgwqdw iiapegyaaf ycdgecsfpl nahmnatnha ivqtlvhlmf pdhvpkpcca ptklnaisvl yfddssnvil kkyrnmvvrs cgch
Storage : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
OfficialSymbol : BMP5
Gene Name : BMP5 bone morphogenetic protein 5 [ Homo sapiens ]
Synonyms : BMP5; bone morphogenetic protein 5; MGC34244; BMP-5; OTTHUMP00000016650
Gene ID : 653
mRNA Refseq : NM_021073
Protein Refseq : NP_066551
MIM : 112265
UniProt ID : P22003
Chromosome Location : 6p12.1
Pathway : TGF-beta signaling pathway
Function : BMP receptor binding; cytokine activity; growth factor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What is the role of the protein BMP5 in cellular signaling? 12/01/2022

BMP5, a member of the bone morphogenetic protein family, functions by binding to cell surface receptors and activating the Smad signaling pathway. This leads to the phosphorylation and nuclear localization of transcription factors, thereby regulating gene expression. BMP5 plays a crucial role in cellular proliferation, differentiation, and fate determination. Its signaling mechanism involves various molecular regulations, including the involvement of co-receptors, signal transduction mediators, and downstream effectors.

What are the downstream target genes regulated by BMP5? 02/18/2022

BMP5 regulates the expression of various downstream target genes involved in multiple cellular processes. These include genes encoding transcription factors, extracellular matrix components, growth factors, and signaling molecules. Examples of BMP5 target genes include Runx2, Osterix, Sox9, Noggin, and Gremlin. Through the activation of these target genes, BMP5 influences cell fate determination, osteoblast differentiation, chondrogenesis, and tissue homeostasis.

How does BMP5 contribute to skeletal development and bone formation? 08/03/2021

BMP5 plays a critical role in skeletal development and bone formation. It promotes the commitment of mesenchymal stem cells to the osteoblast lineage and stimulates their differentiation into mature osteoblasts. BMP5 also regulates the proliferation and survival of osteoblasts, as well as the synthesis and mineralization of the extracellular matrix. Additionally, BMP5 interacts with other BMP family members and signaling molecules to coordinate the complex processes of skeletal patterning, limb development, and bone remodeling.

What is the involvement of BMP5 in pathological conditions, such as skeletal disorders and cancer? 07/28/2021

Dysregulation of BMP5 expression or signaling has been implicated in various skeletal disorders, including osteoporosis, osteoarthritis, and skeletal dysplasias. BMP5 mutations or alterations in its expression levels can disrupt normal bone development and contribute to skeletal abnormalities. Additionally, BMP5 has been found to play a role in cancer progression. Depending on the context, BMP5 can act as either a tumor suppressor or a promoter by influencing cell proliferation, apoptosis, angiogenesis, and metastasis.

What are the current challenges and future directions in BMP5 research? 02/20/2019

Despite significant progress, several challenges remain in BMP5 research. Understanding the precise mechanisms underlying BMP5 signaling and its cross-talk with other signaling pathways is crucial. Additionally, investigating the context-dependent functions of BMP5 in different tissues and disease conditions is important for developing targeted therapies. Future research should focus on elucidating the regulatory networks controlling BMP5 expression and identifying novel therapeutic targets within the BMP5 signaling pathway. Moreover, studying the potential of BMP5 as a diagnostic or prognostic marker in various diseases would further expand its clinical relevance.

How is the expression of BMP5 regulated in different tissues and developmental stages? 05/10/2017

The expression of BMP5 is tightly regulated through a combination of transcriptional, post-transcriptional, and post-translational mechanisms. Transcription factors, such as Smads, homeobox proteins, and other tissue-specific regulators, bind to the promoter region of the BMP5 gene, modulating its expression. Additionally, microRNAs and RNA-binding proteins can influence the stability and translation of BMP5 mRNA. Furthermore, epigenetic modifications, including DNA methylation and histone acetylation, play a role in regulating BMP5 expression during development and in response to environmental cues.

Are there any therapeutic implications of targeting BMP5 in disease treatment? 04/14/2017

Targeting BMP5 signaling holds therapeutic potential for various diseases. For example, in bone-related disorders, modulating BMP5 activity could be explored to promote bone regeneration or inhibit excessive bone loss. In cancer, therapeutic strategies targeting BMP5 signaling could be designed to regulate tumor growth, metastasis, or sensitize cancer cells to existing therapies. However, further research is needed to fully understand the complex role of BMP5 in disease pathogenesis and to develop targeted therapies that specifically modulate BMP5 activity.

Customer Reviews (3)

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Reviews
01/19/2021

    Revolutionizing the art of experimentation, this reagent blazes a trail of innovation.

    03/05/2020

      By using this reagent, I am able to delve deeper into my research topics, deriving more persuasive conclusions.

      03/25/2017

        The reagent showcases remarkable versatility and unwavering stability when it comes to the manipulation of intricate samples.

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