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Recombinant Human CD3E protein, His/Fc-tagged
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Cat.No. : | CD3E-8541H Optional Service: Optional requirements on this protein |
Product Overview : | Recombinant Human CD3E (Asp23-Asp126) protein was fused to human IgG1 Fc/His-tag at C-terminus and expressed in human 293 cells (HEK293). |
Description : | CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2. |
Source : | HEK293 |
Species : | Human |
Tag : | His/human IgG1 Fc |
Predicted N Terminal : | Asp23 |
Form : | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 39.2 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | Asp23-Asp126 |
Endotoxin : | Less than 1.0 EU per μg by the LAL method. |
Purity : | >95% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents. |
SDS-PAGE of CD3E-8541H : |
![]() Human CD3 epsilon, Fc,His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. |
Bioactivity-ELISA of CD3E-8541H : |
![]() Immobilized Anti Human CD3 MAb, mouse IgG1 at 2 μg/mL (100 μL/well) can bind Human CD3 epsilon, Fc,His Tag with a linear range of 0.1-3 ng/mL (Routinely tested). |
Gene Name : | CD3E |
Official Symbol : | CD3E |
Synonyms : | CD3E; CD3e molecule, epsilon (CD3-TCR complex); CD3e antigen, epsilon polypeptide (TiT3 complex); T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell antigen receptor complex, epsilon subunit of T3; T3E; TCRE; FLJ18683 |
Gene ID : | 916 |
mRNA Refseq : | NM_000733 |
Protein Refseq : | NP_000724 |
MIM : | 186830 |
UniProt ID : | P07766 |
◆ Recombinant Protein
CD3E-2193H | Recombinant Human CD3E Protein, His-Avi-tagged, Biotinylated | +Inquiry |
CD3E-675H | Recombinant Human CD3E Protein, His-tagged | +Inquiry |
Cd3e-839M | Recombinant Mouse Cd3e Protein, MYC/DDK-tagged | +Inquiry |
CD3E-463H | Recombinant Human CD3E Protein (Met1-Asp126), His-tagged, Biotinylated | +Inquiry |
CD3E-321H | Recombinant Human CD3E Protein, His-tagged | +Inquiry |
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◆ Lysates
CD3E-1602CCL | Recombinant Cynomolgus CD3E cell lysate | +Inquiry |
CD3E-1275HCL | Recombinant Human CD3E cell lysate | +Inquiry |
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