Active Recombinant Human PARK7, GST-tagged

• Cat.No.: PARK7-115H
• Product Overview: Recombinant Human PARK7 fused with GST-tag at N-terminal, was expressed in E. coli.

Specification

• Cat. No.: PARK7-115H
• Description: The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
• Source: E. coli
• Molecular Mass: 19.9 kDa
• Activity: Cleaved DJ-1 was assayed for protease activity.
• Purity: Greater than 95%, as determined by SDS-PAGE.
• Applications: ELISA, WB, Protease Activity Determination.
• Storage: Purified DJ-1 is supplied as sterile and frozen at 1 mg/ml in 50 mM Tris-Cl/150mM NaCl, pH=8.0. Store at 2-4ºC for immediate use within 1-2 weeks or at –80ºC for up to 12 months. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: PARK7

Gene Information

• Gene Name: PARK7 Parkinson disease (autosomal recessive, early onset) 7 [ Homo sapiens ]
• Synonyms: PARK7; Parkinson disease (autosomal recessive, early onset) 7; DJ1; DJ-1; FLJ27376; FLJ34360; FLJ92274; Parkinson disease protein 7; oncogene DJ1; oncogene DJ1; protein DJ-1; OTTHUMP00000001350; OTTHUMP00000001351; OTTHUMP00000001348; OTTHUMP00000001349
• Gene ID: 11315
• mRNA Refseq: NM_001123377
• Protein Refseq: NP_001116849
• MIM: 602533
• UniProt ID: Q99497
• Chromosome Location: 1p36.23
• Pathway: Parkinson's disease; Alpha-synuclein signaling
• Function: peroxiredoxin activity; protein binding