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Recombinant Human PROC, His-tagged

Cat. No. : PROC-59H
Product Overview : Recombinant Human Vitamin K-Dependent Protein C/PROC(Thr19-Pro461), fused with a polyhistidine tag at the C-terminus was expressed in HEK293 Cells.
Description : This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
Source : HEK293
Purity : Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Shipping : The product is shipped on dry ice/ice packs.
Endotoxin : Less than 0.1 ng/µg (1 IEU/µg).
OfficialSymbol : PROC
Gene Name : PROC protein C (inactivator of coagulation factors Va and VIIIa) [ Homo sapiens ]
Synonyms : PROC; protein C (inactivator of coagulation factors Va and VIIIa); PC; PROC1; Vitamin K-dependent protein C; Autoprothrombin IIA; Anticoagulant protein C; Blood coagulation factor XIV; Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide; EC 3.4.21.69; protein C; protein C (inactivator of coagulation factors Va and VIIIa)
Gene ID : 5624
mRNA Refseq : NM_000312
Protein Refseq : NP_000303
MIM : 612283
UniProt ID : P04070
Chromosome Location : 2q13-q14
Pathway : Complement and coagulation cascades; Hemostasis; Metabolism of proteins; aling in Immune system
Function : calcium ion binding; protein binding; serine-type endopeptidase activity

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