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Recombinant Human PROC, His-tagged

Cat. No.: PROC-59H
Product Overview: Recombinant Human Vitamin K-Dependent Protein C/PROC(Thr19-Pro461), fused with a polyhistidine tag at the C-terminus was expressed in HEK293 Cells.
Description: This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.
Source: HEK293
Purity: Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.
Shipping: The product is shipped on dry ice/ice packs.
Endotoxin: Less than 0.1 ng/µg (1 IEU/µg).
OfficialSymbol: PROC
Gene Name: PROC protein C (inactivator of coagulation factors Va and VIIIa) [ Homo sapiens ]
Synonyms: PROC; protein C (inactivator of coagulation factors Va and VIIIa); PC; PROC1; Vitamin K-dependent protein C; Autoprothrombin IIA; Anticoagulant protein C; Blood coagulation factor XIV; Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide; EC 3.4.21.69; protein C; protein C (inactivator of coagulation factors Va and VIIIa)
Gene ID: 5624
mRNA Refseq: NM_000312
Protein Refseq: NP_000303
MIM: 612283
UniProt ID: P04070
Chromosome Location: 2q13-q14
Pathway: Complement and coagulation cascades; Hemostasis; Metabolism of proteins; aling in Immune system
Function: calcium ion binding; protein binding; serine-type endopeptidase activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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