"MMP3" Related Products


Recombinant Human MMP3

Cat. No. : MMP3-197H
Product Overview : Recombinant human MMP3, encoding the human MMP3 (AAA36321.1) N-terminal fragment (Tyr 18-Thr 272) was expressed in E. coli.
Description : Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP''s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Source : E. coli
Molecular Mass : This protein has a calculated molecular mass of 29 KDa. It migrates as an approximately 34 KDa band in SDS-PAGE under reducing conditions.
Purity : Greater than 97% as determined by SDS-PAGE.
Formulation : Lyophilized from sterile 50mM Tris, 10mM CaCL2, 1uM ZnCL2, 50mM NaCL, 0.5% Brij35, PH7.0
Predicted N terminal : Met 1
Bio-activity : The activity was measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPKPVE-Nval-WRK(Dnp)-NH2. The specific activity is >300 pmoles/min/μg.
Storage : Store at -70°C. Avoid multiple freeze-thaw cycles.
OfficialSymbol : MMP3
Gene Name : MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [ Homo sapiens ]
Synonyms : matrix metallopeptidase 3 (stromelysin 1, progelatinase); SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; MGC126102; transin-1; MMP3; MGC126103; matrix metalloproteinase 3; CHDS6; Transin-1; proteoglycanase; MGC126104; Matrix metalloproteinase-3; EC
Gene ID : 4314
mRNA Refseq : NM_002422
Protein Refseq : NP_002413
MIM : 185250
UniProt ID : P08254
Chromosome Location : 11q22.3
Function : calcium ion binding; metalloendopeptidase activity; peptidase activity; zinc ion binding

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