Recombinant Human CAMLG, His-tagged
Cat.No. : | CAMLG-15870H |
Product Overview : | Recombinant human CAMLG protein, fused to His tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Description : | The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. CAMLG functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol |
Molecular Mass : | 23.2 kDa (212aa), confirmed by MALDI-TOF |
Protein length : | 1-189aa |
AA Sequence : | MGSSHHHHHH SSGLVPRGSH MGSMESMAVA TDGGERPGVP AGSGLSASQR RAELRRRKLL MNSEQRINRI MGFHRPGSGA EEESQTKSKQ QDSDKLNSLS VPSVSKRVVL GDSVSTGTTD QQGGVAEVKG TQLGDKLDSF IKPPECSSDV NLELRQRNRG DLTADSVQRG SRHGLEQYLS RFEEAMKLRK QLISEKPSQE DGNTTEEFDS FR |
Purity : | >85% by SDS - PAGE |
Applications : | SDS-PAGE |
Storage : | Can be stored at 4°C short term. For long term storage, aliquot and store at at -20°C or -70°C. Avoid repeated freezing and thawing cycles. |
Concentration : | 0.5 mg/ml (determined by Bradford assay) |
Gene Name : | CAMLG calcium modulating ligand [ Homo sapiens ] |
Official Symbol : | CAMLG |
Synonyms : | CAMLG; calcium modulating ligand; calcium signal-modulating cyclophilin ligand; calcium modulating cyclophilin ligand; calcium signal modulating cyclophilin ligand; CAML; cyclophilin B binding protein; cyclophilin B-binding protein; calcium-modulating cyclophilin ligand; calcium-signal modulating cyclophilin ligand; MGC163197; |
Gene ID : | 819 |
mRNA Refseq : | NM_001745 |
Protein Refseq : | NP_001736 |
MIM : | 601118 |
UniProt ID : | P49069 |
Chromosome Location : | 5q23 |
Function : | protein binding; |
Products Types
◆ Recombinant Protein | ||
CAMLG-0344H | Recombinant Human CAMLG Protein, GST-Tagged | +Inquiry |
Camlg-584R | Recombinant Rat Camlg Protein, His/GST-tagged | +Inquiry |
CAMLG-1202M | Recombinant Mouse CAMLG Protein, His (Fc)-Avi-tagged | +Inquiry |
Caml-583M | Recombinant Mouse Caml Protein, His-tagged | +Inquiry |
CAMLG-446R | Recombinant Rhesus Macaque CAMLG Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CAMLG-7872HCL | Recombinant Human CAMLG 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket