Recombinant Human AARS2, His-tagged

• Cat.No.: AARS2-9197H
• Product Overview: Recombinant human AARS2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 635-985a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: AARS2 alanyl-tRNA synthetase 2, mitochondrial (putative) [ Homo sapiens ]
• Official Symbol: AARS2
• Synonyms: AARS2; alanyl-tRNA synthetase 2, mitochondrial (putative); AARSL, alanyl tRNA synthetase like; alanine--tRNA ligase, mitochondrial; alanine tRNA ligase 2; mitochondrial (putative); bA444E17.1; KIAA1270; alanyl-tRNA synthetase like; probable alanyl-tRNA synthetase, mitochondrial; alanine tRNA ligase 2, mitochondrial (putative); AARSL; COXPD8; MTALARS; MT-ALARS
• Gene ID: 57505
• mRNA Refseq: NM_020745
• Protein Refseq: NP_065796
• MIM: 612035
• UniProt ID: Q5JTZ9
• Chromosome Location: 6p21.1
• Pathway: Aminoacyl-tRNA biosynthesis, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, conserved biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, organism-specific biosystem; Aminoacyl-tRNA biosynthesis, eukaryotes, conserved biosystem; Gene Expression, organism-specific biosystem; Mitochondrial tRNA aminoacylation, organism-specific biosystem; tRNA Aminoacylation, organism-specific biosystem
• Function: ATP binding; alanine-tRNA ligase activity; ligase activity; metal ion binding; nucleotide binding; tRNA binding