Recombinant Human ACADS, His-tagged

• Cat.No.: ACADS-9269H
• Product Overview: Recombinant Human ACADS protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Mutations in this gene have been associated with Short Chain Acyl-CoA Dehydrogenase Deficiency.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-412a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain [ Homo sapiens ]
• Official Symbol: ACADS
• Synonyms: ACADS; acyl-CoA dehydrogenase, C-2 to C-3 short chain; acyl Coenzyme A dehydrogenase, C 2 to C 3 short chain; short-chain specific acyl-CoA dehydrogenase, mitochondrial; ACAD3; SCAD; butyryl-CoA dehydrogenase; unsaturated acyl-CoA reductase; short-chain acyl-CoA dehydrogenase; acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain; mitochondrial short-chain specific acyl-CoA dehydrogenase
• Gene ID: 35
• mRNA Refseq: NM_000017
• Protein Refseq: NP_000008
• MIM: 606885
• UniProt ID: P16219
• Chromosome Location: 12q24.31
• Pathway: Beta oxidation of butanoyl-CoA to acetyl-CoA, organism-specific biosystem; Beta oxidation of hexanoyl-CoA to butanoyl-CoA, organism-specific biosystem; Butanoate metabolism, organism-specific biosystem; Butanoate metabolism, conserved biosystem; Fatty Acid Beta Oxidation, organism-specific biosystem; Fatty acid metabolism, organism-specific biosystem; Fatty acid metabolism, conserved biosystem
• Function: acyl-CoA dehydrogenase activity; butyryl-CoA dehydrogenase activity; fatty-acyl-CoA binding; flavin adenine dinucleotide binding

Reviews

03/16/2022

Performs well in detecting endogenous levels of the target protein in complex biological samples.

06/19/2021

Displays excellent cross-reactivity with related proteins in immunoassays.

Q&As

Are there any known inhibitors or activators of this protein?

There are currently no known inhibitors or activators of acyl-CoA dehydrogenase short chain protein.

What is the function of acyl-CoA dehydrogenase short chain protein?

Acyl-CoA dehydrogenase short chain protein catalyzes the first step in the 尾-oxidation of short-chain fatty acids.

What research is currently being conducted to further understand the function of acyl-CoA dehydrogenase short chain protein?

Research is ongoing to further understand the function and regulation of acyl-CoA dehydrogenase short chain protein, as well as its role in metabolic disorders.

What is the substrate specificity of this protein?

Acyl-CoA dehydrogenase short chain protein has specificity for short-chain fatty acyl-CoA substrates.

How does the activity of this protein contribute to cellular metabolism?

The activity of acyl-CoA dehydrogenase short chain contributes to the breakdown of short-chain fatty acids to produce energy in cells.

What are the physiological roles of acyl-CoA dehydrogenase short chain?

Acyl-CoA dehydrogenase short chain plays a key role in energy metabolism and fatty acid oxidation in cells.

Where is acyl-CoA dehydrogenase short chain protein located within the cell?

Acyl-CoA dehydrogenase short chain protein is located in the mitochondrial matrix.

How is the expression of acyl-CoA dehydrogenase short chain regulated?

The expression of acyl-CoA dehydrogenase short chain is regulated by a variety of factors, including gene expression and protein degradation pathways.

What is the structure of this protein and how does it relate to its function?

Acyl-CoA dehydrogenase short chain protein has a flavin adenine dinucleotide (FAD)-binding domain that is essential for its function.

What diseases or disorders are associated with mutations in this protein?

Mutations in this protein are associated with a variety of metabolic disorders, including short-chain acyl-CoA dehydrogenase deficiency.