Recombinant Human ACTN1, GST-tagged ACTN1-9339H

Recombinant Human ACTN1, GST-tagged

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Recombinant Human ACTN1, GST-tagged

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Cat.No. : ACTN1-9339H
Product Overview : Recombinant Human ACTN1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : GST
Protein length : C-term-350a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ACTN1 actinin, alpha 1 [ Homo sapiens ]
Official Symbol : ACTN1
Synonyms : ACTN1; actinin, alpha 1; alpha-actinin-1; actinin 1 smooth muscle; non-muscle alpha-actinin-1; F-actin cross-linking protein; alpha-actinin cytoskeletal isoform; FLJ40884; FLJ54432;
Gene ID : 87
mRNA Refseq : NM_001102
Protein Refseq : NP_001093
MIM : 102575
UniProt ID : P12814
Chromosome Location : 14q24.1
Pathway : Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Amoebiasis, organism-specific biosystem; Amoebiasis, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cell junction organization, organism-specific biosystem;
Function : actin binding; actin filament binding; calcium ion binding; integrin binding; ion channel binding; protein binding; protein domain specific binding; vinculin binding;

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