Recombinant Human ADH1A, His-tagged

• Cat.No.: ADH1A-9416H
• Product Overview: Recombinant Human ADH1A protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Description: This gene encodes a member of the alcohol dehydrogenase family. The encoded protein is the alpha subunit of class I alcohol dehydrogenase, which consists of several homo- and heterodimers of alpha, beta and gamma subunits. Alcohol dehydrogenases catalyze the oxidation of alcohols to aldehydes. This gene is active in the liver in early fetal life but only weakly active in adult liver. This gene is found in a cluster with six additional alcohol dehydrogenase genes, including those encoding the beta and gamma subunits, on the long arm of chromosome 4. Mutations in this gene may contribute to variation in certain personality traits and substance dependence.
• Source: E.coli
• Species: Human
• Tag: His
• Protein length: 1-375a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide [ Homo sapiens ]
• Official Symbol: ADH1A
• Synonyms: ADH1A; alcohol dehydrogenase 1A (class I), alpha polypeptide; ADH1; alcohol dehydrogenase 1A; ADH, alpha subunit; aldehyde reductase; alcohol dehydrogenase subunit alpha; alcohol dehydrogenase 1 (class I), alpha polypeptide
• Gene ID: 124
• mRNA Refseq: NM_000667
• Protein Refseq: NP_000658
• MIM: 103700
• UniProt ID: P07327
• Chromosome Location: 4q23
• Pathway: Biological oxidations, organism-specific biosystem; Drug metabolism - cytochrome P450, organism-specific biosystem; Drug metabolism - cytochrome P450, conserved biosystem; Ethanol oxidation, organism-specific biosystem; Fatty Acid Omega Oxidation, organism-specific biosystem; Fatty acid metabolism, organism-specific biosystem; Fatty acid metabolism, conserved biosystem
• Function: alcohol dehydrogenase activity, zinc-dependent; metal ion binding; nucleotide binding; oxidoreductase activity; protein binding; zinc ion binding