"ADRBK1" Related Products

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Recombinant Human ADRBK1, His-tagged

Cat.No. : ADRBK1-9445H
Product Overview : Recombinant Human ADRBK1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Source : E.coli
Species : Human
Tag : His
Protein length : 390-689a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : ADRBK1 adrenergic, beta, receptor kinase 1 [ Homo sapiens ]
Official Symbol : ADRBK1
Synonyms : ADRBK1; adrenergic, beta, receptor kinase 1; beta-adrenergic receptor kinase 1; BARK1; GRK2; beta-ARK-1; G-protein coupled receptor kinase 2; BETA-ARK1; FLJ16718;
Gene ID : 156
mRNA Refseq : NM_001619
Protein Refseq : NP_001610
MIM : 109635
UniProt ID : P25098
Chromosome Location : 11q13
Pathway : CXCR4-mediated signaling events, organism-specific biosystem; Ca-dependent events, organism-specific biosystem; CaM pathway, organism-specific biosystem; Calmodulin induced events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; DAG and IP3 signaling, organism-specific biosystem;
Function : ATP binding; Edg-2 lysophosphatidic acid receptor binding; G-protein coupled receptor kinase activity; alpha-2A adrenergic receptor binding; beta-adrenergic receptor kinase activity; nucleotide binding; protein binding; protein kinase activity;

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