Recombinant Human ADRBK1, His-tagged

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Recombinant Human ADRBK1, His-tagged

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Cat.No. : ADRBK1-9445H
Product Overview : Recombinant Human ADRBK1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Source : E.coli
Species : Human
Tag : His
Protein length : 390-689a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : ADRBK1 adrenergic, beta, receptor kinase 1 [ Homo sapiens ]
Official Symbol : ADRBK1
Synonyms : ADRBK1; adrenergic, beta, receptor kinase 1; beta-adrenergic receptor kinase 1; BARK1; GRK2; beta-ARK-1; G-protein coupled receptor kinase 2; BETA-ARK1; FLJ16718;
Gene ID : 156
mRNA Refseq : NM_001619
Protein Refseq : NP_001610
MIM : 109635
UniProt ID : P25098
Chromosome Location : 11q13
Pathway : CXCR4-mediated signaling events, organism-specific biosystem; Ca-dependent events, organism-specific biosystem; CaM pathway, organism-specific biosystem; Calmodulin induced events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; DAG and IP3 signaling, organism-specific biosystem;
Function : ATP binding; Edg-2 lysophosphatidic acid receptor binding; G-protein coupled receptor kinase activity; alpha-2A adrenergic receptor binding; beta-adrenergic receptor kinase activity; nucleotide binding; protein binding; protein kinase activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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