Recombinant Human ALG11, His-tagged

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Recombinant Human ALG11, His-tagged

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Cat.No. : ALG11-9571H
Product Overview : Recombinant Human ALG11 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description : This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19.
Source : E.coli
Species : Human
Tag : His
Protein length : 1-328a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : ALG11 asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast) [ Homo sapiens ]
Official Symbol : ALG11
Synonyms : AI849156; alg11; ALG11_HUMAN; Asparagine-linked glycosylation 11; Asparagine-linked glycosylation 11, alpha-1,2-mannosyltransferase homolog (yeast); Asparagine-linked glycosylation protein 11 homolog; AW492253; B230397C21; GT8; KIAA0266; OTTMUSP00000022781; RGD1564725
Gene ID : 440138
mRNA Refseq : NM_001004127.2
Protein Refseq : NP_001004127.2
MIM : 613666
UniProt ID : Q2TAA5
Chromosome Location : 13q14.2
Pathway : Asparagine N-linked glycosylation, organism-specific biosystem; Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; N-Glycan biosynthesis, organism-specific biosystem; N-Glycan biosynthesis, conserved biosystem; N-glycan precursor biosynthesis, organism-specific biosystem; N-glycan precursor biosynthesis, conserved biosystem
Function : GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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