Recombinant Human ALKBH3, GST-tagged ALKBH3-9584H

Recombinant Human ALKBH3, GST-tagged

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Recombinant Human ALKBH3, GST-tagged

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Cat.No. : ALKBH3-9584H
Product Overview : Recombinant Human ALKBH3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).
Source : E.coli
Species : Human
Tag : GST
Protein length : C-term-139a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ALKBH3 alkB, alkylation repair homolog 3 (E. coli) [ Homo sapiens ]
Official Symbol : ALKBH3
Synonyms : ALKBH3; alkB, alkylation repair homolog 3 (E. coli); alpha-ketoglutarate-dependent dioxygenase alkB homolog 3; DEPC 1; prostate cancer antigen 1; prostate cancer antigen-1; alkylated DNA repair protein alkB homolog 3; ABH3; PCA1; DEPC1; DEPC-1; FLJ43614; MGC118790; MGC118792; MGC118793;
Gene ID : 221120
mRNA Refseq : NM_139178
Protein Refseq : NP_631917
MIM : 610603
UniProt ID : Q96Q83
Chromosome Location : 11p11.2
Pathway : ABH3 mediated Reversal of Alkylation Damage, organism-specific biosystem; DNA Damage Reversal, organism-specific biosystem; DNA Repair, organism-specific biosystem; Reversal of Alkylation Damage By DNA Dioxygenases, organism-specific biosystem;
Function : DNA-N1-methyladenine dioxygenase activity; L-ascorbic acid binding; cytosine C-5 DNA demethylase activity; ferrous iron binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular o

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