Recombinant Human ALS2, His-tagged
Cat.No. : | ALS2-9600H |
Product Overview : | Recombinant Human ALS2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose. |
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Description : | The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | His |
Protein length : | N-term-304a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol. |
Publication : |
Fabrication, assessment, and optimization of alendronate sodium nanoemulsion-based injectable in-situ gel formulation for management of osteoporosis (2022)
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Gene Name : | ALS2 amyotrophic lateral sclerosis 2 (juvenile) [ Homo sapiens ] |
Official Symbol : | ALS2 |
Synonyms : | ALS2; amyotrophic lateral sclerosis 2 (juvenile); ALS2CR6, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6; alsin; amyotrophic lateral sclerosis 2 protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; ALSJ; PLSJ; IAHSP; ALS2CR6; FLJ31851; KIAA1563; MGC87187; |
Gene ID : | 57679 |
mRNA Refseq : | NM_001135745 |
Protein Refseq : | NP_001129217 |
MIM : | 606352 |
UniProt ID : | Q96Q42 |
Chromosome Location : | 2q33-q35 |
Pathway : | Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem; |
Function : | Rab GTPase binding; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; Ran guanyl-nucleotide exchange factor activity; contributes_to guanyl-nucleotide exchange factor activity; protein homo |
Products Types
◆ Recombinant Protein | ||
ALS2-298R | Recombinant Rat ALS2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALS2-491M | Recombinant Mouse ALS2 Protein, His (Fc)-Avi-tagged | +Inquiry |
ALS2-166H | Recombinant Human ALS2 Protein, His-tagged | +Inquiry |
ALS2-1577M | Recombinant Mouse ALS2 Protein | +Inquiry |
ALS2-497H | Recombinant Human ALS2 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ALS2-66HCL | Recombinant Human ALS2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALS2 contains functional domains, including RhoGAP and VPS9 domains, which contribute to its GTPase activity, protein interactions, or membrane association.
ALS2 plays a role in regulating axonal growth, neurite outgrowth, or cytoskeletal organization, potentially influencing neuronal development and connectivity.
ALS2 exhibits a predominantly cytoplasmic localization, with possible associations with endosomes, the Golgi apparatus, or cytoskeletal structures.
Dysregulation or mutations in ALS2 can contribute to motor neuron degeneration in ALS, a progressive neurodegenerative disorder characterized by the selective loss of motor neurons in the brain and spinal cord.
ALS2 expression levels can vary among different tissues and cell types, and they are regulated by factors such as developmental cues, cellular stress, or specific signaling pathways.
Genetic variations or mutations in ALS2 have been associated with juvenile forms of ALS and hereditary spastic paraplegia, suggesting their impact on ALS2 function and disease pathogenesis.
ALS2 interacts with various proteins involved in vesicle trafficking, cytoskeletal dynamics, or signaling cascades, forming complexes critical for its functional roles.
Post-translational modifications, such as phosphorylation or acetylation, can regulate ALS2 function, stability, or interactions with other proteins.
Targeting ALS2 or its associated pathways may offer potential therapeutic strategies for ALS and related motor neuron disorders, aiming to restore neuronal connectivity, enhance vesicle trafficking, or alleviate cellular stress in affected motor neurons.
ALS2 modulates signaling pathways, such as the Rho GTPase signaling pathway, which are involved in cytoskeletal dynamics, vesicle transport, or cellular responses to extracellular signals.
Customer Reviews (3)
Write a reviewRobust antibody for immunoprecipitation experiments.
Excellent signal-to-noise ratio in assays.
Accurate determination of protein-protein interaction kinetics.
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