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Recombinant Human ALS2, His-tagged

Cat.No. : ALS2-9600H
Product Overview : Recombinant Human ALS2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : His
Protein length : N-term-304a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Publication :
Fabrication, assessment, and optimization of alendronate sodium nanoemulsion-based injectable in-situ gel formulation for management of osteoporosis (2022)
Gene Name : ALS2 amyotrophic lateral sclerosis 2 (juvenile) [ Homo sapiens ]
Official Symbol : ALS2
Synonyms : ALS2; amyotrophic lateral sclerosis 2 (juvenile); ALS2CR6, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 6; alsin; amyotrophic lateral sclerosis 2 protein; amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein; ALSJ; PLSJ; IAHSP; ALS2CR6; FLJ31851; KIAA1563; MGC87187;
Gene ID : 57679
mRNA Refseq : NM_001135745
Protein Refseq : NP_001129217
MIM : 606352
UniProt ID : Q96Q42
Chromosome Location : 2q33-q35
Pathway : Amyotrophic lateral sclerosis (ALS), organism-specific biosystem; Amyotrophic lateral sclerosis (ALS), conserved biosystem;
Function : Rab GTPase binding; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activity; Rac guanyl-nucleotide exchange factor activity; Ran guanyl-nucleotide exchange factor activity; contributes_to guanyl-nucleotide exchange factor activity; protein homo

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What are the functional domains and motifs within ALS2, and how do they contribute to its enzymatic activities or protein-protein interactions? 12/24/2021

ALS2 contains functional domains, including RhoGAP and VPS9 domains, which contribute to its GTPase activity, protein interactions, or membrane association.

What is the role of ALS2 in axonal growth, neuronal development, or cytoskeletal organization? 08/22/2021

ALS2 plays a role in regulating axonal growth, neurite outgrowth, or cytoskeletal organization, potentially influencing neuronal development and connectivity.

What are the subcellular localization patterns of ALS2 and its association with cellular compartments or organelles? 05/27/2021

ALS2 exhibits a predominantly cytoplasmic localization, with possible associations with endosomes, the Golgi apparatus, or cytoskeletal structures.

How does ALS2 contribute to motor neuron degeneration in the context of amyotrophic lateral sclerosis (ALS)? 10/01/2020

Dysregulation or mutations in ALS2 can contribute to motor neuron degeneration in ALS, a progressive neurodegenerative disorder characterized by the selective loss of motor neurons in the brain and spinal cord.

How does ALS2 expression vary across different tissues and cell types, and what factors regulate its expression levels? 03/04/2020

ALS2 expression levels can vary among different tissues and cell types, and they are regulated by factors such as developmental cues, cellular stress, or specific signaling pathways.

Can genetic variations or mutations in ALS2 lead to alterations in ALS2 function or expression, and how do they relate to the pathogenesis of ALS or other neurodegenerative diseases? 03/30/2019

Genetic variations or mutations in ALS2 have been associated with juvenile forms of ALS and hereditary spastic paraplegia, suggesting their impact on ALS2 function and disease pathogenesis.

How does ALS2 interact with other proteins and form complexes involved in cellular processes or signaling pathways? 01/19/2019

ALS2 interacts with various proteins involved in vesicle trafficking, cytoskeletal dynamics, or signaling cascades, forming complexes critical for its functional roles.

What are the post-translational modifications that regulate ALS2 activity, stability, or subcellular localization? 08/23/2018

Post-translational modifications, such as phosphorylation or acetylation, can regulate ALS2 function, stability, or interactions with other proteins.

Can therapeutic interventions targeting ALS2 or its associated pathways provide potential strategies for treating ALS or related motor neuron disorders? 12/02/2017

Targeting ALS2 or its associated pathways may offer potential therapeutic strategies for ALS and related motor neuron disorders, aiming to restore neuronal connectivity, enhance vesicle trafficking, or alleviate cellular stress in affected motor neurons.

What are the downstream signaling pathways or cellular processes modulated by ALS2, and how do they impact neuronal function or cellular homeostasis? 06/02/2017

ALS2 modulates signaling pathways, such as the Rho GTPase signaling pathway, which are involved in cytoskeletal dynamics, vesicle transport, or cellular responses to extracellular signals.

Customer Reviews (3)

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Reviews
11/13/2017

    Robust antibody for immunoprecipitation experiments.

    07/21/2017

      Excellent signal-to-noise ratio in assays.

      01/21/2017

        Accurate determination of protein-protein interaction kinetics.

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