Recombinant Human AMD1, GST-tagged
Cat.No. : | AMD1-9610H |
Product Overview : | Recombinant Human AMD1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | This gene encodes an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. Two alternatively spliced transcript variants that encode different proteins have been identified. Pseudogenes of this gene are found on chromosomes 5, 6, 10, X and Y. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-334a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | AMD1 adenosylmethionine decarboxylase 1 [ Homo sapiens ] |
Official Symbol : | AMD1 |
Synonyms : | AMD1; adenosylmethionine decarboxylase 1; S adenosylmethionine decarboxylase 1; S-adenosylmethionine decarboxylase proenzyme; SAMDC; S-adenosylmethionine decarboxylase 1; AMD; ADOMETDC; FLJ26964; DKFZp313L1234; |
Gene ID : | 262 |
mRNA Refseq : | NM_001033059 |
Protein Refseq : | NP_001028231 |
MIM : | 180980 |
UniProt ID : | P17707 |
Chromosome Location : | 6q21 |
Pathway : | Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; |
Function : | adenosylmethionine decarboxylase activity; adenosylmethionine decarboxylase activity; lyase activity; |
Products Types
◆ Recombinant Protein | ||
AMD1-130H | Recombinant Human AMD1 Protein, His-tagged | +Inquiry |
AMD1-303R | Recombinant Rat AMD1 Protein, His (Fc)-Avi-tagged | +Inquiry |
Amd1-591M | Recombinant Mouse Amd1 Protein, MYC/DDK-tagged | +Inquiry |
AMD1-122H | Recombinant Human AMD1 protein, T7-tagged | +Inquiry |
AMD1-516H | Recombinant Human AMD1 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
AMD1-8886HCL | Recombinant Human AMD1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMD1 interacts with other enzymes, such as ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (SAMDC), in the polyamine biosynthetic pathway, forming a regulatory network.
Alterations in AMD1 expression or activity have been observed in various diseases, including cancer, suggesting its potential as a diagnostic marker or therapeutic target for specific conditions.
AMD1 expression is regulated at the transcriptional level by various factors, including growth factors, hormones, and cellular stressors.
AMD1 represents a potential pharmacological target for modulating polyamine metabolism, and its inhibition has been explored as a therapeutic strategy in diseases such as cancer.
AMD1 deficiency or inhibition can lead to altered polyamine levels and impaired cellular processes, including reduced cell proliferation and compromised cell survival.
AMD1 plays a key role in polyamine biosynthesis, regulating the levels of polyamines such as putrescine, spermidine, and spermine, which are involved in cell growth, proliferation, and differentiation.
AMD1 is an enzyme that catalyzes the conversion of S-adenosylmethionine (SAM) to decarboxylated SAM, which is a crucial step in the biosynthesis of polyamines.
The catalytic activity and substrate specificity of AMD1 are determined by its unique protein structure, including active site residues and cofactor binding sites.
AMD1 activity influences downstream signaling pathways, including mTOR signaling, DNA methylation, and gene expression, which are involved in cell growth and proliferation.
The substrates of AMD1 include SAM, the primary methyl donor in cellular methylation reactions, and its decarboxylated product, which serves as a precursor for polyamine synthesis.
Customer Reviews (3)
Write a reviewCompatibility with high-resolution imaging techniques for detailed analysis.
Accurate measurement of protein turnover rates.
Reduced non-specific binding in antibody-based assays.
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