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Recombinant Human ANXA7, GST-tagged

Cat.No.: ANXA7-9700H
Product Overview: Recombinant Human ANXA7 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.
Source: E.coli
Species: Human
Tag: GST
Protein length: 236-466a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: ANXA7 annexin A7 [ Homo sapiens ]
Official Symbol: ANXA7
Synonyms: ANXA7; annexin A7; ANX7; annexin-7; annexin VII; SNX; SYNEXIN;
Gene ID: 310
mRNA Refseq: NM_001156
Protein Refseq: NP_001147
MIM: 186360
UniProt ID: P20073
Chromosome Location: 10q22.2
Function: calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; protein binding;

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