Recombinant Human AP1M1, GST-tagged
Cat.No. : | AP1M1-9710H |
Product Overview : | Recombinant Human AP1M1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | C-term-260a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | AP1M1 adaptor-related protein complex 1, mu 1 subunit [ Homo sapiens ] |
Official Symbol : | AP1M1 |
Synonyms : | AP1M1; adaptor-related protein complex 1, mu 1 subunit; AP-1 complex subunit mu-1; AP47; CLAPM2; mu-adaptin 1; mu1A-adaptin; HA1 47 kDa subunit; clathrin adaptor protein AP47; AP-mu chain family member mu1A; golgi adaptor AP-1 47 kDa protein; clathrin coat assembly protein AP47; clathrin coat-associated protein AP47; adaptor protein complex AP-1 mu-1 subunit; golgi adaptor HA1/AP1 adaptin mu-1 subunit; adaptor-related protein complex 1 mu-1 subunit; clathrin assembly protein complex 1, medium chain; clathrin assembly protein complex AP1, mu subunit; clathrin assembly protein complex 1 medium chain 1; CLTNM; MU-1A; |
Gene ID : | 8907 |
mRNA Refseq : | NM_001130524 |
Protein Refseq : | NP_001123996 |
MIM : | 603535 |
UniProt ID : | Q9BXS5 |
Chromosome Location : | 19p13.12 |
Pathway : | Clathrin derived vesicle budding, organism-specific biosystem; Disease, organism-specific biosystem; E-cadherin signaling in the nascent adherens junction, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; HIV Infection, organism-specific biosystem; Host Interactions of HIV factors, organism-specific biosystem; Lysosome, organism-specific biosystem; |
Function : | protein binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (19)
Ask a questionIt is still in the research stage, and further experiments and clinical trials are needed to determine the application prospects of AP1M1 in the field of cell therapy.
The structure of AP1M1 is a polypeptide chain, consisting of multiple amino acid residues, which contain a number of functional domains. The specific structure varies depending on the sample source and preparation method.
A standard dose of AP1M1 has not yet been determined, and this will require further clinical trials to determine.
The mechanism of action of AP1M1 is to achieve therapeutic effects by regulating pathways such as intracellular protein transport and membrane topology maintenance.
At present, the clinical application of AP1M1 is still in the research stage, but its potential use includes the treatment of some cancers, autoimmune diseases and so on.
No AP1M1 has been found to induce a significant immune response, but allergies need to be checked frequently.
At present, there is no toxicity problem of AP1M1 in clinical treatment. However, in the process of use, the patient's physical condition and allergies and other factors need to be considered.
In clinical treatment, adverse reactions of AP1M1 are rare, but side effects such as allergic reactions may occur.
In addition to areas currently being explored such as cancer and autoimmune diseases, the recombinant AP1M1 protein has potential applications in areas such as neurological diseases and metabolic diseases.
The production process of AP1M1 includes protein expression, cell culture, protein purification, quality control and storage.
The specific role of the AP1M1 remains to be studied, but its wide distribution within cells suggests that it may have broad-spectrum effects.
The recombinant AP1M1 protein can be expressed and purified in cells or cell culture through genetic engineering technology.
The AP1M1 is a protein encoded by the AP1M1 gene in the human protein-coding genome. It is responsible for participating in many important biological processes within the cell, such as protein transport and cell membrane topology maintenance.
With further research and clinical trials of AP1M1 , it is expected to become a new therapeutic means and bring great help for the treatment of related diseases.
There are currently no large-scale tolerance studies, but short-term clinical trial results show that the AP1M1 is widely tolerated.
Further studies are needed to determine the pharmacokinetic and pharmacodynamic interactions of recombinant AP1M1 with other drugs.
At present, the research of AP1M1 is still relatively preliminary, and further clinical trials and basic research are needed to determine its clinical application prospects.
At present, the dosage form of AP1M1 has not been determined, and further studies are needed to determine it.
The efficacy of AP1M1 in clinical trials needs to be further demonstrated, but the current preliminary study shows its potential therapeutic effect.
Customer Reviews (4)
Write a reviewIt has the characteristics of short half-life and high clearance, which makes it act quickly in the body and clear quickly, improving the efficiency of treatment.
Unmatched repeatability and highly consistent performance under all conditions make it ideal for use in experiments or applications that require a high degree of repeatability.
Stability is very good, after many repeated use, its performance remains stable, showing good product quality.
The production process has minimal impact on the environment and truly achieves green production.
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