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Recombinant Human APOBEC3C, GST-tagged

Cat.No. : APOBEC3C-9755H
Product Overview : Recombinant Human APOBEC3C protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-190a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C [ Homo sapiens ]
Official Symbol : APOBEC3C
Synonyms : APOBEC3C; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C; probable DNA dC->dU-editing enzyme APOBEC-3C; APOBEC1L; ARDC2; ARDC4; ARP5; bK150C2.3; PBI; probable DNA dC-> dU-editing enzyme APOBEC-3C; phorbolin I; A3C; FLJ37251; MGC19485;
Gene ID : 27350
mRNA Refseq : NM_014508
Protein Refseq : NP_055323
MIM : 607750
UniProt ID : Q9NRW3
Chromosome Location : 22q13.1-q13.2
Function : hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; metal ion binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (16)

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What techniques are used to study APOBEC3C? 10/07/2022

Research on APOBEC3C involves techniques such as gene expression analysis, protein assays, next-generation sequencing, immunohistochemistry, and cell-based assays. These techniques help understand its expression, protein-protein interactions, and functional consequences.

Can APOBEC3C induce DNA mutations in human cells? 12/02/2021

There is limited evidence suggesting that APOBEC3C can induce DNA mutations in human cells. However, its mutational activity may be weaker compared to other APOBEC3 proteins.

How does APOBEC3C compare to other members of the APOBEC3 protein family? 08/01/2021

APOBEC3C shares structural similarities with other APOBEC3 proteins but has distinct functional characteristics. It has been found to have weaker antiviral activity than some other members, such as APOBEC3A and APOBEC3G.

What viruses are targeted by APOBEC3C? 06/14/2021

APOBEC3C has been shown to have activity against retroviruses like HIV-1 and other related viruses. However, its antiviral activity against other viruses is not well-characterized.

Is APOBEC3C associated with any human diseases? 02/05/2021

Currently, there is no direct evidence linking APOBEC3C to any specific human diseases. However, it is possible that dysregulation or mutations in APOBEC3C could play a role in virus-related diseases or cancer development.

How is APOBEC3C expression regulated? 09/19/2020

The regulation of APOBEC3C expression is not well-studied. However, similar to other APOBEC3 family members, it is likely regulated at the transcriptional level by various factors and signaling pathways.

Are there any known interactions of APOBEC3C with other cellular proteins? 09/09/2019

APOBEC3C has been reported to interact with certain proteins involved in antiviral defense and DNA repair pathways, such as APOBEC3G, A3G mRNA-binding protein, and RAD52. These interactions suggest possible functional crosstalk between different proteins in these pathways.

How does APOBEC3C contribute to the innate immune response against viral infections? 11/28/2018

APOBEC3C, like other APOBEC3 proteins, acts as a host innate immune defense against viral infections. By deaminating viral DNA or RNA, it disrupts viral replication or leads to the degradation of viral genetic material.

Does APOBEC3C play a role in drug resistance? 08/26/2018

There is limited information available regarding APOBEC3C's role in drug resistance. Further research is needed to understand its potential involvement in this process.

Are there any known inhibitors or activators of APOBEC3C? 06/13/2018

As of now, there are no specific inhibitors or activators known for APOBEC3C. Further research is needed to identify molecules that can modulate its activity.

Are there any ongoing research studies or clinical trials focused on APOBEC3C? 02/16/2018

Currently, there are no specific ongoing research studies or clinical trials focused solely on APOBEC3C. However, as more is understood about its functions and relevance in human diseases, it may become a subject of future investigations.

What are the potential implications of APOBEC3C mutations or dysregulation in cancer? 01/24/2018

Although not extensively studied, APOBEC3C mutations or dysregulation could potentially contribute to cancer development or progression. Some studies have shown an association between elevated APOBEC3C expression and certain types of cancer.

Can APOBEC3C be targeted for therapeutic interventions? 05/31/2017

Targeting APOBEC3C for therapeutic interventions is still an area of active research. Modulation of its activity or expression could potentially be explored as a strategy against specific viral infections or virus-associated diseases.

Is APOBEC3C expressed in normal tissues? 05/06/2016

APOBEC3C is expressed at low levels in various normal tissues, such as testis, lung, and liver. However, its expression pattern and physiological functions in normal tissues are not well-characterized.

Can APOBEC3C be used as a biomarker for any diseases or conditions? 04/12/2016

Currently, there is limited evidence suggesting APOBEC3C as a potential biomarker for certain cancers. However, further research is needed to validate its diagnostic or prognostic value.

Are there any genetic polymorphisms associated with APOBEC3C? 04/02/2016

Studies have identified genetic variations or single-nucleotide polymorphisms (SNPs) in the APOBEC3C gene. However, their functional implications and potential association with diseases are still not well-understood.

Customer Reviews (4)

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Reviews
02/21/2023

    I highly recommend the APOBEC3C protein for a wide range of research applications.

    06/17/2018

      The APOBEC3C protein's robustness and stability have contributed significantly to the success of my experiments, enabling precise and reproducible measurements.

      07/02/2017

        Its ability to preserve structural integrity and facilitate high-resolution imaging has greatly enhanced my understanding of protein complexes and their interactions.

        08/24/2016

          Furthermore, the APOBEC3C protein has demonstrated great utility in protein electron microscopy structure analysis.

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