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Recombinant Human ARL1, His-tagged

Cat.No. : ARL1-9847H
Product Overview : Recombinant Human ARL1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
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Description : The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.
Source : E.coli
Species : Human
Tag : His
Protein length : 1-181a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : ARL1 ADP-ribosylation factor-like 1 [ Homo sapiens ]
Official Symbol : ARL1
Synonyms : ARL1; ADP-ribosylation factor-like 1; ADP-ribosylation factor-like protein 1; ARFL1;
Gene ID : 400
mRNA Refseq : NM_001177
Protein Refseq : NP_001168
MIM : 603425
UniProt ID : P40616
Chromosome Location : 12q23.3
Function : GTP binding; GTPase activity; enzyme activator activity; metal ion binding; nucleotide binding; protein domain specific binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (16)

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Can ARL1 protein be post-translationally modified? 01/24/2023

Yes, ARL1 can undergo post-translational modifications such as lipidation with myristate or palmitate groups. These modifications aid in membrane association and regulate the localization and function of ARL1 in vesicular trafficking.

Are there any ARL1-related genetic disorders? 10/29/2022

Currently, there are no known genetic disorders directly associated with ARL1 mutations. However, dysregulation of vesicular trafficking processes, for which ARL1 is essential, can contribute to pathological conditions. Further research may uncover potential links between ARL1 dysfunction and specific genetic disorders.

Can ARL1 be involved in cellular processes other than vesicular trafficking? 08/12/2021

While the primary role of ARL1 is in vesicular trafficking, recent studies have suggested additional functions for ARL1 in autophagy, cilia formation, and cytoskeleton organization. These emerging roles expand the potential impact of ARL1 in maintaining cellular homeostasis.

Is ARL1 involved in any disease processes? 04/24/2021

While there is no direct association between ARL1 mutations and specific diseases, dysregulation of ARL1-mediated vesicular trafficking processes can contribute to pathological conditions. For example, defects in Golgi-ER trafficking and autophagy have been linked to neurodegenerative diseases and cancer, suggesting potential roles for ARL1 dysfunction in these disorders.

Is ARL1 protein expressed ubiquitously in all cell types? 09/04/2020

ARL1 is expressed in a wide range of cell types and tissues, suggesting its ubiquitous presence in most cellular systems. However, its expression levels may vary depending on the specific cell type and the physiological state of the cell.

Are there any known ARL1-related signaling pathways? 06/26/2020

ARL1 itself is not extensively involved in signaling pathways. However, its interactions with effector proteins indirectly contribute to the regulation of various signaling cascades, such as the Wnt signaling pathway and the MAPK/ERK pathway, which are crucial for cell growth, development, and differentiation.

Are there any diseases associated with ARL1 dysfunction? 06/23/2020

Currently, no specific human diseases have been directly linked to ARL1 dysfunction. However, alterations in vesicular trafficking processes, for which ARL1 is essential, can contribute to various pathological conditions such as neurodegenerative disorders and certain cancers.

Are there any drugs or compounds that modulate ARL1 activity? 06/17/2020

Currently, there are no specific drugs or compounds developed to directly modulate ARL1 activity. However, as our understanding of ARL1 function advances, it may provide insights into potential targets for therapeutic intervention in diseases related to vesicular trafficking defects.

Does ARL1 have any specific subcellular localization? 06/09/2019

ARL1 is primarily localized to the Golgi apparatus and the ER, where it regulates vesicular trafficking events between these organelles. However, studies have also reported a partial distribution of ARL1 in other cellular compartments, including the plasma membrane and the trans-Golgi network, suggesting its involvement in diverse membrane trafficking pathways.

How does ARL1 interact with other small GTPases? 11/15/2018

ARL1 shares similarities with other small GTPases, such as the ADP-ribosylation factor (ARF) proteins. While ARL1 and ARF proteins belong to the same GTPase superfamily, they have distinct functions and interactions with specific effector proteins. However, cross-talk between ARL1 and ARF proteins may occur in some cellular contexts, regulating membrane trafficking processes.

How does ARL1 contribute to organelle dynamics and membrane trafficking? 10/22/2018

ARL1 regulates the recruitment and actions of effector proteins involved in vesicle tethering, fusion, and cargo sorting between the Golgi apparatus and ER. By facilitating these processes, ARL1 ensures efficient and accurate transport of proteins and lipids, maintaining the overall integrity and function of the endomembrane system within the cell.

Does ARL1 protein have any known interacting partners? 05/21/2018

Yes, ARL1 interacts with various effector proteins involved in vesicular trafficking, such as GRIP domain-containing ARF-binding protein 2 (GGA2), golgin subfamily A member 1 (GOLGA1), and golgin subfamily B member 1 (GOLGB1). These interactions facilitate the targeting and fusion of vesicles at specific cellular compartments.

What are the cellular consequences of ARL1 knockout or depletion? 12/14/2017

Depletion or knockout of ARL1 in cells has been reported to cause disrupted Golgi-ER trafficking, altered lysosome morphology, impaired autophagy, and defects in cilia formation. These consequences highlight the critical role of ARL1 in maintaining organelle dynamics and cellular processes.

What are the current areas of research regarding ARL1 protein? 04/27/2017

Current research on ARL1 focuses on elucidating its precise molecular mechanisms and identifying additional binding partners and effector proteins. Additionally, studies are exploring the functional implications of ARL1 in diseases with vesicular trafficking defects, which may offer new therapeutic strategies.

Can ARL1 protein be targeted for therapeutic purposes? 11/15/2016

Currently, no specific therapeutics have been developed to directly target ARL1. However, understanding its role in vesicular trafficking may provide insights into potential therapeutic strategies for diseases associated with dysregulated vesicular transport processes.

How is ARL1 protein activated? 08/21/2016

ARL1 protein is activated by the exchange of GDP (guanosine diphosphate) for GTP (guanosine triphosphate) through the action of guanine nucleotide exchange factors (GEFs). Once activated, ARL1 interacts with effector proteins to carry out its cellular functions.

Customer Reviews (8)

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Reviews
11/05/2022

    The ARL1 protein is renowned for its exceptional quality, making it a perfect match for my experimental requirements.

    06/15/2020

      Researchers have successfully utilized ARL1 protein in electron microscopy studies, unraveling crucial insights into protein interactions and conformational changes.

      11/20/2019

        This can involve organizing conferences, workshops, and webinars to discuss the latest advancements, share research findings, and broaden the understanding of ARL1 function

        03/25/2019

          the ARL1 protein exhibits superior performance across a range of experimental applications.

          09/30/2018

            In addition to its high-quality attributes, the manufacturer of the ARL1 protein offers exemplary technical support.

            10/17/2017

              The exceptional performance of ARL1 protein in both ELISA and protein electron microscopy structure analysis positions it as a valuable tool in a broad range of research applications.

              07/03/2016

                This technical support is invaluable, especially for researchers who may be new to working with ARL1 protein or if they encounter specific difficulties while conducting their experiments.

                01/26/2016

                  Its versatility allows for its successful implementation in diverse areas such as molecular biology, cellular assays, and protein-protein interactions.

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