Recombinant Human ARPC4, GST-tagged
Cat.No. : | ARPC4-9885H |
Product Overview : | Recombinant Human ARPC4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Description : | This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-168a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa [ Homo sapiens ] |
Official Symbol : | ARPC4 |
Synonyms : | ARPC4; actin related protein 2/3 complex, subunit 4, 20kDa; actin related protein 2/3 complex, subunit 4 (20 kD); actin-related protein 2/3 complex subunit 4; actin related protein 2/3 complex; subunit 4 (20 kD); ARC20; Arp2/3 protein complex subunit p20; p20 Arc; arp2/3 complex 20 kDa subunit; arp2/3 protein complex subunit p20; P20-ARC; MGC13544; |
Gene ID : | 10093 |
mRNA Refseq : | NM_001024959 |
Protein Refseq : | NP_001020130 |
MIM : | 604226 |
UniProt ID : | P59998 |
Chromosome Location : | 3p25 |
Pathway : | B Cell Receptor Signaling Pathway, organism-specific biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; CDC42 signaling events, organism-specific biosystem; ErbB1 downstream signaling, organism-specific biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem; |
Function : | contributes_to actin filament binding; protein binding; contributes_to protein binding, bridging; |
Products Types
◆ Recombinant Protein | ||
ARPC4-0532H | Recombinant Human ARPC4 Protein (Ala3-Leu165), N-His-tagged | +Inquiry |
ARPC4-300H | Recombinant Human ARPC4 Protein, His-tagged | +Inquiry |
ARPC4-4611C | Recombinant Chicken ARPC4 | +Inquiry |
Arpc4-1694M | Recombinant Mouse Arpc4 protein, His-tagged | +Inquiry |
Arpc4-1695R | Recombinant Rat Arpc4 protein, His-tagged | +Inquiry |
◆ Lysates | ||
ARPC4-8684HCL | Recombinant Human ARPC4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionYes, ARPC4 expression can be influenced by extracellular signals. Various signaling pathways, such as the Rho GTPase pathway and growth factor signaling, can activate or inhibit the expression of genes encoding ARPC4 and other subunits of the ARP2/3 complex, thereby modulating actin cytoskeleton dynamics.
At present, there are no specific drugs or compounds known to directly modulate ARPC4 activity. However, targeting actin cytoskeleton dynamics and actin regulatory proteins that indirectly affect ARPC4 function has shown potential in preclinical studies as therapeutic approaches for various diseases.
Mutations in the ARPC4 gene have not been directly linked to any specific diseases. However, dysregulation of the ARP2/3 complex, including ARPC4, has been implicated in several pathological conditions such as cancer metastasis, neurological disorders, and immune system dysfunction.
ARPC4 is considered a ubiquitously expressed protein, meaning it is expressed in a wide range of tissues and cell types throughout the body. Its expression is necessary for essential cellular processes involving actin cytoskeleton dynamics.
Yes, ARPC4 interacts with other subunits of the ARP2/3 complex, including ARPC1, ARPC2, ARPC3, ARPC5, and ARPC6. Additionally, ARPC4 can interact with actin-binding proteins, such as cortactin and coronin, which regulate actin filament assembly and stability.
Yes, alterations in ARPC4 expression levels can impact cell migration. The ARP2/3 complex, including ARPC4, is essential for actin filament nucleation and branching, which are crucial for cell motility. Changes in ARPC4 expression can disrupt proper actin cytoskeletal dynamics, impairing cell migration.
Yes, changes in ARPC4 expression can impact cell division. The ARP2/3 complex, including ARPC4, is involved in actin-dependent processes during cell division, such as cytokinesis and chromosome segregation. Disruption of ARPC4 expression can lead to defects in these cellular processes.
Customer Reviews (3)
Write a reviewRenowned for its reliability and consistency, this protein offers researchers the confidence to achieve accurate and reproducible results in their studies.
One notable advantage of the ARPC4 protein is the excellent technical support provided by its manufacturer.
The ARPC4 protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.
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