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Recombinant Human ASAP3, GST-tagged

Cat.No. : ASAP3-9912H
Product Overview : Recombinant Human ASAP3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : This gene encodes a member of a subfamily of ADP-ribosylation factor(Arf) GTPase-activating proteins that contain additional ankyrin repeat and pleckstrin homology domains. The Arf GAP domain of this protein catalyzes the hydrolysis of GTP bound to Arf proteins. The encoded protein promotes cell differentiation and migration and has been implicated in cancer cell invasion. Alternative splicing results in multiple transcript variants.
Source : E.coli
Species : Human
Tag : GST
Protein length : 558-903a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 [ Homo sapiens ]
Official Symbol : ASAP3
Synonyms : ASAP3; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3; DDEFL1, development and differentiation enhancing factor like 1; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3; centaurin; beta 6; CENTB6; FLJ20199; UPLC1; centaurin, beta 6; ARF6 GTPase-activating protein; protein up-regulated in liver cancer 1; up-regulated in liver cancer 1 (UPLC1); development and differentiation enhancing factor-like 1; development and differentiation-enhancing factor-like 1; ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 1; ACAP4; DDEFL1;
Gene ID : 55616
mRNA Refseq : NM_001143778
Protein Refseq : NP_001137250
UniProt ID : Q8TDY4
Chromosome Location : 1p36.13
Pathway : Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Fc gamma R-mediated phagocytosis, organism-specific biosystem; Fc gamma R-mediated phagocytosis, conserved biosystem;
Function : ARF GTPase activator activity; metal ion binding; zinc ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (8)

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Is ASAP3 expressed in immune cells? 03/30/2023

ASAP3 has been found in immune cells, indicating its potential involvement in immune responses, though its exact functions in this context remain to be fully elucidated.

Does ASAP3 play a role in cell adhesion? 02/21/2023

Yes, ASAP3 is involved in cell adhesion processes by regulating the internalization and recycling of adhesion molecules, such as integrins, at the plasma membrane.

Can ASAP3 be regulated by post-translational modifications? 01/06/2023

Yes, ASAP3 can undergo phosphorylation, acetylation, and ubiquitination, which can affect its stability, activity, and protein-protein interactions.

How does ASAP3 regulate membrane trafficking? 10/07/2022

ASAP3 stimulates the GTP hydrolysis of Arf6, leading to its inactivation and subsequent modulation of vesicle trafficking pathways, including endocytosis and recycling.

Is ASAP3 involved in cancer progression? 05/02/2022

ASAP3 has been suggested to play a role in cancer cell invasion and metastasis due to its influence on cell migration, adhesion, and the actin cytoskeleton.

Are there any genetic variations associated with ASAP3? 03/13/2022

Genetic variations in ASAP3 have been identified, and some studies have linked them to certain diseases or phenotypes, although further research is needed to establish definitive associations.

Can ASAP3 interact with other proteins? 06/30/2021

Yes, ASAP3 can interact with various proteins involved in membrane trafficking, including clathrin, AP1, AP2, and several adaptor proteins.

Does ASAP3 play a role in neuronal processes? 09/07/2017

ASAP3 expression has been observed in neurons, suggesting a potential role in neuronal development, synaptic plasticity, or other neuronal processes, although more investigation is required.

Customer Reviews (3)

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03/15/2022

    The outstanding level of customer service adds extra reassurance and confidence in using the ASAP3 protein for my scientific investigations.

    09/29/2019

      With the ASAP3 protein and its accompanying technical assistance, I am confident that I can achieve successful outcomes for my research endeavors.

      10/23/2018

        The ASAP3 protein offers numerous advantages in trials and research studies, making it an excellent choice for scientists in need of reliable and high-quality experimental materials.

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