Recombinant Human BAAT, GST-tagged

• Cat.No.: BAAT-10119H
• Product Overview: Recombinant Human BAAT protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 1-418a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: BAAT bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase) [ Homo sapiens ]
• Official Symbol: BAAT
• Synonyms: BAAT; bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase); bile acid Coenzyme A: amino acid N acyltransferase (glycine N choloyltransferase); bile acid-CoA:amino acid N-acyltransferase; BAT; long-chain fatty-acyl-CoA hydrolase; bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase); BACAT; FLJ20300; MGC104432
• Gene ID: 570
• mRNA Refseq: NM_001127610
• Protein Refseq: NP_001121082
• MIM: 602938
• UniProt ID: Q14032
• Chromosome Location: 9q22.3
• Pathway: Bile acid and bile salt metabolism, organism-specific biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Biosynthesis of unsaturated fatty acids, organism-specific biosystem; Biosynthesis of unsaturated fatty acids, conserved biosystem; Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate, organism-specific biosystem
• Function: N-acyltransferase activity; carboxylesterase activity; glycine N-choloyltransferase activity; hydrolase activity; palmitoyl-CoA hydrolase activity; thiolester hydrolase activity; transferase activity, transferring acyl groups