Recombinant Human BAG1, His-tagged

• Cat.No.: BAG1-10124H
• Product Overview: Recombinant Human BAG1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: C-term-310a.a.
• Description: The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: BAG1 BCL2-associated athanogene [ Homo sapiens ]
• Official Symbol: BAG1
• Synonyms: BAG1; BCL2-associated athanogene; BAG family molecular chaperone regulator 1; BAG-1; Bcl-2-binding protein; receptor-associated protein, 46-KD; Bcl-2 associating athanogene-1 protein; glucocortoid receptor-associated protein RAP46; HAP; RAP46
• Gene ID: 573
• mRNA Refseq: NM_001172415
• Protein Refseq: NP_001165886
• MIM: 601497
• UniProt ID: Q99933
• Chromosome Location: 9p12
• Pathway: Androgen Receptor Signaling Pathway, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem
• Function: chaperone binding; phosphoprotein binding; protein binding; receptor signaling protein activity