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Recombinant Human BCR, His-tagged

Cat.No.: BCR-10196H
Product Overview: Recombinant Human BCR protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: His
Protein length: 1-350a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: BCR breakpoint cluster region [ Homo sapiens ]
Official Symbol: BCR
Synonyms: BCR; breakpoint cluster region; BCR1, D22S11; breakpoint cluster region protein; ALL; CML; D22S662; PHL; renal carcinoma antigen NY-REN-26; BCR1; D22S11; FLJ16453;
Gene ID: 613
mRNA Refseq: NM_004327
Protein Refseq: NP_004318
MIM: 151410
UniProt ID: P11274
Chromosome Location: 22q11
Pathway: Chronic myeloid leukemia, organism-specific biosystem; Chronic myeloid leukemia, conserved biosystem; Pathways in cancer, organism-specific biosystem; Regulation of RAC1 activity, organism-specific biosystem; Regulation of RhoA activity, organism-specific biosystem; Rho GTPase cycle, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function: ATP binding; GTPase activator activity; Rac GTPase activator activity; Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; kinase activity; nucleotide binding; protein serine/threonine kinase activity; transferase a

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