Recombinant Human BPNT1, GST-tagged BPNT1-10277H

Recombinant Human BPNT1, GST-tagged

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Recombinant Human BPNT1, GST-tagged

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Cat.No. : BPNT1-10277H
Product Overview : Recombinant Human BPNT1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : BPNT1, also called bisphosphate 3-prime-nucleotidase, or BPntase, is a member of a magnesium-dependent phosphomonoesterase family. Lithium, a major drug used to treat manic depression, acts as an uncompetitive inhibitor of BPntase. The predicted human protein is 92% identical to mouse BPntase. BPntases physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. The inhibition of human BPntase may account for lithium-induced nephrotoxicity.
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-325a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : BPNT1 3(2), 5-bisphosphate nucleotidase 1 [ Homo sapiens ]
Official Symbol : BPNT1
Synonyms : BPNT1; 3(2), 5-bisphosphate nucleotidase 1; 3(2),5-bisphosphate nucleotidase 1; BPntase; PAP-inositol-1,4-phosphatase; bisphosphate 3-nucleotidase 1; PIP;
Gene ID : 10380
mRNA Refseq : NM_006085
Protein Refseq : NP_006076
MIM : 604053
UniProt ID : O95861
Chromosome Location : 1q42
Pathway : Biological oxidations, organism-specific biosystem; Cytosolic sulfonation of small molecules, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Phase II conjugation, organism-specific biosystem; Sulfur metabolism, organism-specific biosystem; Sulfur metabolism, conserved biosystem;
Function : 3(2),5-bisphosphate nucleotidase activity; hydrolase activity; magnesium ion binding;

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