Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at BIO-Europe Spring|March 18–20, 2024|Booth #34

Recombinant Human C5, His-tagged

Cat.No. : C5-10539H
Product Overview : Recombinant Human C5 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
Description : The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
Source : E.coli
Species : Human
Tag : His
Protein length : C-term-259a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : C5 complement component 5 [ Homo sapiens ]
Official Symbol : C5
Synonyms : C5; complement component 5; complement C5; CPAMD4; anaphylatoxin C5a analog; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4; FLJ17816; FLJ17822; MGC142298;
Gene ID : 727
mRNA Refseq : NM_001735
Protein Refseq : NP_001726
MIM : 120900
UniProt ID : P01031
Chromosome Location : 9q33-q34
Pathway : Activation of C3 and C5, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Complement Activation, Classical Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Complement cascade, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem;
Function : C5a anaphylatoxin chemotactic receptor binding; chemokine activity; endopeptidase inhibitor activity; receptor binding;

Products Types

◆ Recombinant Protein
C5-2711M Recombinant Mouse C5 Protein, His-tagged +Inquiry
C5-0052H Recombinant Human C5 Protein (G981-Q1306), Tag Free +Inquiry
C5-348P Recombinant Pig C5 Protein, His-tagged +Inquiry
C5-345H Recombinant Human C5 Protein, His-tagged +Inquiry
C5-344H Recombinant Human C5 Protein, His-tagged +Inquiry

See All C5 Recombinant Protein

◆ Native Protein
C5-10540H Active Native Human C5 +Inquiry
C5-53H Native Human Complement C5 +Inquiry

See All C5 Native Protein

◆ Lysates
C5-8020HCL Recombinant Human C5 293 Cell Lysate +Inquiry

See All C5 Lysates

Related Gene

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can C5 inhibition be a potential therapy for neuroinflammatory conditions such as multiple sclerosis? 01/10/2023

Yes, C5 inhibition has shown promise in treating multiple sclerosis by modulating the inflammatory response and reducing damage to the central nervous system.

How is the C5 protein targeted in therapeutic interventions, and what are the available modalities? 08/25/2022

C5 can be targeted using monoclonal antibodies, such as eculizumab, which inhibits its activity. This approach has been successful in managing various complement-related disorders.

How is the C5 protein involved in the pathogenesis of diseases like PNH? 02/21/2019

In PNH, a mutation leads to uncontrolled complement activation, resulting in the destruction of red blood cells. Inhibiting C5 can prevent this process and improve clinical outcomes.

How does C5 inhibition impact the risk of infections in patients undergoing treatment? 11/16/2016

C5 inhibition can increase susceptibility to certain infections. Close monitoring and appropriate preventive measures are essential to manage the infection risk in patients receiving C5-targeted therapies.

What role does C5 play in the progression of inflammatory diseases like rheumatoid arthritis? 09/01/2016

In rheumatoid arthritis, C5 contributes to inflammation and joint damage. Targeting C5 in treatment may help mitigate the inflammatory response.

Customer Reviews (3)

Write a review
Reviews
09/29/2019

    Whether I am studying protein interactions, cellular localization, or signaling pathways, the C5 protein consistently delivers reliable and reproducible data, enabling significant scientific advancements.

    10/23/2018

      Its superior purity and stability ensure reliable and accurate results, instilling confidence in my research.

      11/20/2016

        Their assistance has been invaluable in streamlining my experiments and overcoming obstacles effectively.

        Ask a Question for All C5 Products

        Required fields are marked with *

        My Review for All C5 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends