Recombinant Human CACNA2D3, GST-tagged

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Recombinant Human CACNA2D3, GST-tagged

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Cat.No. : CACNA2D3-10636H
Product Overview : Recombinant Human CACNA2D3 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Source : E.coli
Species : Human
Tag : GST
Protein length : C-term-305a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 [ Homo sapiens ]
Official Symbol : CACNA2D3
Synonyms : CACNA2D3; calcium channel, voltage-dependent, alpha 2/delta subunit 3; voltage-dependent calcium channel subunit alpha-2/delta-3; HSA272268; calcium channel alpha2-delta3 subunit; voltage-gated calcium channel subunit alpha-2/delta-3; calcium channel, voltage-dependent, alpha 2/delta 3 subunit;
Gene ID : 55799
mRNA Refseq : NM_018398
Protein Refseq : NP_060868
MIM : 606399
UniProt ID : Q8IZS8
Chromosome Location : 3p21.1
Pathway : Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem; Dilated cardiomyopathy, organism-specific biosystem; Dilated cardiomyopathy, conserved biosystem;
Function : metal ion binding; voltage-gated calcium channel activity; voltage-gated ion channel activity;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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