Recombinant Human CACYBP, GST-tagged
Cat.No. : | CACYBP-10648H |
Product Overview : | Recombinant Human CACYBP protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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- Gene Information
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Description : | The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-228a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | CACYBP calcyclin binding protein [ Homo sapiens ] |
Official Symbol : | CACYBP |
Synonyms : | CACYBP; calcyclin binding protein; calcyclin-binding protein; S100A6BP; SIP; hCacyBP; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein; GIG5; PNAS-107; RP1-102G20.6; MGC87971; |
Gene ID : | 27101 |
mRNA Refseq : | NM_001007214 |
Protein Refseq : | NP_001007215 |
MIM : | 606186 |
UniProt ID : | Q9HB71 |
Chromosome Location : | 1q24-q25 |
Pathway : | Wnt signaling pathway, organism-specific biosystem; Wnt signaling pathway, conserved biosystem; |
Function : | protein binding; protein homodimerization activity; |
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◆ Lysates | ||
CACYBP-7898HCL | Recombinant Human CACYBP 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPhosphorylation of CACYBP can modulate its protein-protein interactions and stability. Phosphorylation events may affect its role in cell cycle regulation and ubiquitin-dependent protein degradation.
CACYBP's calcium-binding domains undergo conformational changes upon calcium binding, which can affect its interactions with other proteins. It allows CACYBP to act as a calcium-dependent scaffold for various signaling complexes.
CACYBP interacts with Cyclins and CDKs, forming complexes that regulate the phosphorylation of key cell cycle regulators. These interactions affect the progression through different phases of the cell cycle.
CACYBP functions as an adaptor protein in ubiquitin-dependent protein degradation by facilitating the transfer of ubiquitin moieties to target proteins. It forms complexes with E3 ubiquitin ligases and substrates, directing them to the proteasome for degradation.
CACYBP participates in stress responses by modulating the stability and activity of proteins involved in stress pathways. For example, it can influence the stability of DNA repair proteins and oxidative stress response factors, contributing to cellular adaptation to stress conditions.
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