Recombinant Human CDK5R1, His-tagged

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Recombinant Human CDK5R1, His-tagged

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Cat.No. : CDK5R1-11051H
Product Overview : Recombinant Human CDK5R1 was expressed as 6*his-tagged fusion protein by E.Coli and puri?ed by Ni-sepharose.
Description : Cyclin-dependent kinase 5 activator 1 is an enzyme that in humans is encoded by the CDK5R1 gene. The protein encoded by this gene (p35) is neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer"s disease.
Source : E. coli
Species : Human
Tag : His
AA Sequence : 99-307aa
Storage : The protein is stored in PBS bu?er at -20 oC. Repeated freeze-thaw cycles should be avoided.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name : CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) [ Homo sapiens (human) ]
Official Symbol : CDK5R1
Synonyms : CDK5R1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); cyclin-dependent kinase 5 activator 1; Nck5a; p35nck5a; CDK5 activator 1; neuronal CDK5 activator; TPKII regulatory subunit; regulatory partner for CDK5 kinase; tau protein kinase II 23kDa subunit; cyclin-dependent kinase 5 regulatory subunit 1; p23; p25; p35; CDK5R; NCK5A; CDK5P35; MGC33831
Gene ID : 8851
mRNA Refseq : NM_003885
Protein Refseq : NP_003876
MIM : 603460
UniProt ID : Q15078
Chromosome Location : 17q11.2
Pathway : BDNF signaling pathway; Alzheimer's disease; Developmental Biology
Function : cadherin binding; cyclin-dependent protein kinase 5 activator activity; ephrin receptor binding

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