Recombinant Human CISH, GST-tagged
Cat.No. : | CISH-11255H |
Product Overview : | Recombinant Human CISH protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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- Gene Information
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Description : | The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-258a.a. |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | CISH cytokine inducible SH2-containing protein [ Homo sapiens ] |
Official Symbol : | CISH |
Synonyms : | CISH; cytokine inducible SH2-containing protein; cytokine-inducible SH2-containing protein; CIS; CIS 1; G18; SOCS; suppressor of cytokine signaling; cytokine-inducible inhibitor of signaling type 1B; CIS-1; BACTS2; |
Gene ID : | 1154 |
mRNA Refseq : | NM_013324 |
Protein Refseq : | NP_037456 |
MIM : | 602441 |
UniProt ID : | Q9NSE2 |
Chromosome Location : | 3p21.3 |
Pathway : | Cytokine Signaling in Immune system, organism-specific biosystem; ECS complex, organism-specific biosystem; ECS complex, conserved biosystem; EPO Receptor Signaling, organism-specific biosystem; Growth hormone receptor signaling, organism-specific biosystem; IL-2 Signaling Pathway, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem; |
Function : | molecular_function; |
Products Types
◆ Recombinant Protein | ||
CISH-612H | Recombinant Human CISH Protein, His-tagged | +Inquiry |
CISH-1380H | Recombinant Human CISH Protein, GST-tagged | +Inquiry |
Cish-613M | Recombinant Mouse Cish Protein, His-tagged | +Inquiry |
CISH-708R | Recombinant Rhesus Macaque CISH Protein, His (Fc)-Avi-tagged | +Inquiry |
CISH-1700M | Recombinant Mouse CISH Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CISH-7488HCL | Recombinant Human CISH 293 Cell Lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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