Recombinant Human CSTB, GST-tagged CSTB-11649H

Recombinant Human CSTB, GST-tagged

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Recombinant Human CSTB, GST-tagged

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Cat.No. : CSTB-11649H
Product Overview : Recombinant Human CSTB protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description : The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Source : E.coli
Species : Human
Tag : GST
Protein length : 1-98a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : CSTB cystatin B (stefin B) [ Homo sapiens ]
Official Symbol : CSTB
Synonyms : CSTB; cystatin B (stefin B); EPM1, STFB; cystatin-B; CST6; PME; CPI-B; liver thiol proteinase inhibitor; ULD; EPM1; STFB; EPM1A;
Gene ID : 1476
mRNA Refseq : NM_000100
Protein Refseq : NP_000091
MIM : 601145
UniProt ID : P04080
Chromosome Location : 21q22.3
Function : cysteine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; protease binding;

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