Recombinant Human CYLD, GST-tagged

• Cat.No.: CYLD-11760H
• Product Overview: Recombinant Human CYLD protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: C-term-300a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: CYLD cylindromatosis (turban tumor syndrome) [ Homo sapiens ]
• Official Symbol: CYLD
• Synonyms: CYLD; cylindromatosis (turban tumor syndrome); CYLD1; ubiquitin carboxyl-terminal hydrolase CYLD; KIAA0849; ubiquitin specific peptidase like 2; USPL2; ubiquitin thioesterase CYLD; deubiquitinating enzyme CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD; probable ubiquitin carboxyl-terminal hydrolase CYLD; EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLDI; HSPC057; FLJ20180; FLJ31664; FLJ78684
• Gene ID: 1540
• mRNA Refseq: NM_001042355
• Protein Refseq: NP_001035814
• MIM: 605018
• UniProt ID: Q9NQC7
• Chromosome Location: 16q12-q13
• Pathway: Canonical NF-kappaB pathway, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; NOD1/2 Signaling Pathway, organism-specific biosystem; Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem; Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem; Osteoclast differentiation, organism-specific biosystem
• Function: cysteine-type peptidase activity; metal ion binding; peptidase activity; proline-rich region binding; protein binding; protein kinase binding; structural constituent of ribosome; ubiquitin thiolesterase activity; ubiquitin-specific protease activity; zinc