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Recombinant Human CYP2D6, GST-tagged

Cat.No. : CYP2D6-11775H
Product Overview : Recombinant Human CYP2D6 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Description : This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzymes substrates. The gene is located near two cytochrome P450 pseudogenes on chromosome 22q13.1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source : E.coli
Species : Human
Tag : GST
Protein length : 148-497a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 [ Homo sapiens ]
Official Symbol : CYP2D6
Synonyms : CYP2D6; cytochrome P450, family 2, subfamily D, polypeptide 6; CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2 , cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2 , cytochrome P450, subfamily II (debrisoquine, sparteine, etc., metabolising), polypeptide 7 pseudogene 2 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., metabolising), polypeptide 8 pseudogene 2 , cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., metabolizing), polypeptide 6; cytochrome P450 2D6; CPD6; CYP2D; P450 DB1; P450C2D; cytochrome P450-DB1; microsomal monooxygenase; xenobiotic monooxygenase; debrisoquine 4-hydroxylase; flavoprotein-linked monooxygenase; cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2; cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing)-like 1; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6; cytochrome P450, subfamily II (debrisoquine, sparteine, etc., -metabolising), polypeptide 7 pseudogene 2; cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolising), polypeptide 8 pseudogene 2; CYP2DL1; CYPIID6; P450DB1; CYP2D7AP; CYP2D7BP; CYP2D7P2; CYP2D8P2; P450-DB1; MGC120389; MGC120390;
Gene ID : 1565
mRNA Refseq : NM_000106
Protein Refseq : NP_000097
MIM : 124030
UniProt ID : P10635
Chromosome Location : 22q13.1
Pathway : Biological oxidations, organism-specific biosystem; Codeine and morphine metabolism, organism-specific biosystem; Cytochrome P450 - arranged by substrate type, organism-specific biosystem; Drug metabolism - cytochrome P450, organism-specific biosystem; Drug metabolism - cytochrome P450, conserved biosystem; Fatty Acid Omega Oxidation, organism-specific biosystem; Metabolism, organism-specific biosystem;
Function : aromatase activity; drug binding; electron carrier activity; heme binding; heme binding; metal ion binding; monooxygenase activity; monooxygenase activity; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or re

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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How can knowledge of a patient's CYP2D6 genotype impact drug prescribing? 04/08/2023

Knowing a patient's CYP2D6 genotype can help tailor drug therapy, optimizing dosage and minimizing the risk of adverse effects.

How does genetic variability impact the activity of CYP2D6? 07/19/2022

Genetic variations can result in different CYP2D6 phenotypes, influencing an individual's ability to metabolize drugs efficiently.

Are there specific populations that exhibit higher frequencies of CYP2D6 polymorphisms? 03/21/2021

Certain ethnic groups may have a higher prevalence of CYP2D6 polymorphisms, influencing drug response variability among different populations.

What are the clinical implications of CYP2D6 polymorphisms in drug metabolism? 07/23/2020

CYP2D6 polymorphisms can lead to variations in drug response and efficacy, affecting the dosage and choice of medications for patients.

How can CYP2D6 testing be utilized in personalized medicine? 03/18/2019

CYP2D6 testing can guide personalized medicine by helping clinicians choose the most appropriate medications and dosages for individual patients.

Customer Reviews (3)

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01/26/2023

    One remarkable aspect of working with the CYP2D6 protein is the excellent technical support provided by its manufacturer.

    08/15/2022

      The CYP2D6 protein stands out as a protein of exceptional quality, perfectly suited to meet the experimental needs of researchers.

      12/09/2016

        With its reliable performance and consistent results, the CYP2D6 protein provides researchers with the confidence and accuracy required for successful experimentation.

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