Recombinant Human DDOST, His-tagged

• Cat.No.: DDOST-11884H
• Product Overview: Recombinant Human DDOST protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 92-433a.a.
• Description: This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Information

• Gene Name: DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase [ Homo sapiens ]
• Official Symbol: DDOST
• Synonyms: DDOST; dolichyl-diphosphooligosaccharide--protein glycosyltransferase; dolichyl diphosphooligosaccharide protein glycosyltransferase; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; KIAA0115; OST; OST48; WBP1; DDOST 48 kDa subunit; advanced glycation endproduct receptor 1; oligosaccharyltransferase 48 kDa subunit; oligosaccharyl transferase 48 kDa subunit; dolichyl-diphosphooligosaccharide-protein glycotransferase; dolichyl-diphosphooligosaccharide-protein glycosyltransferase; AGER1; CDG1R; OKSWcl45; MGC2191
• Gene ID: 1650
• mRNA Refseq: NM_005216
• Protein Refseq: NP_005207
• MIM: 602202
• UniProt ID: P39656
• Chromosome Location: 1p36.1
• Pathway: Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Asparagine N-linked glycosylation, organism-specific biosystem; Gene Expression, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem
• Function: contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity; contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity; contributes_to oligosaccharyl transferase activity; transferase activity