"DNMT3L" Related Products


Recombinant Human DNMT3L, His-tagged

Cat.No.: DNMT3L-12111H
Product Overview: Recombinant Human DNMT3L protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: His
Protein length: 1-386a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: DNMT3L DNA (cytosine-5-)-methyltransferase 3-like [ Homo sapiens ]
Official Symbol: DNMT3L
Synonyms: DNMT3L; DNA (cytosine-5-)-methyltransferase 3-like; DNA (cytosine-5)-methyltransferase 3-like; cytosine 5 methyltransferase 3 like protein; human cytosine 5 methyltransferase 3 like protein; MGC1090; cytosine-5-methyltransferase 3-like protein; human cytosine-5-methyltransferase 3-like protein;
Gene ID: 29947
mRNA Refseq: NM_013369
Protein Refseq: NP_037501
MIM: 606588
UniProt ID: Q9UJW3
Chromosome Location: 21q22.3
Pathway: Cysteine and methionine metabolism, organism-specific biosystem; Cysteine and methionine metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem; Methionine degradation, organism-specific biosystem; Methionine degradation, conserved biosystem;
Function: enzyme activator activity; enzyme binding; metal ion binding; protein binding;

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