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Recombinant Human DSG1, His-tagged

Cat.No.: DSG1-12178H
Product Overview: Recombinant Human DSG1 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description: Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.
Source: E.coli
Species: Human
Tag: His
Protein length: 756-1049a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.
Gene Name: DSG1 desmoglein 1 [ Homo sapiens ]
Official Symbol: DSG1
Synonyms: DSG1; desmoglein 1; DSG; desmoglein-1; CDHF4; DGI; cadherin family member 4; desmosomal glycoprotein 1; pemphigus foliaceus antigen; DG1; PPKS1; SPPK1;
Gene ID: 1828
mRNA Refseq: NM_001942
Protein Refseq: NP_001933
MIM: 125670
UniProt ID: Q02413
Chromosome Location: 18q12.1
Pathway: Apoptosis, organism-specific biosystem; Apoptotic cleavage of cell adhesionproteins, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; Staphylococcus aureus infection, organism-specific biosystem; Staphylococcus aureus infection, conserved biosystem;
Function: calcium ion binding; gamma-catenin binding; toxin binding;

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