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Recombinant Human ENG, GST-tagged

Cat.No.: ENG-12449H
Product Overview: Recombinant Human ENG protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Source: E.coli
Species: Human
Tag: GST
Protein length: C-term-49a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: ENG endoglin [ Homo sapiens ]
Official Symbol: ENG
Synonyms: ENG; endoglin; ORW, ORW1, Osler Rendu Weber syndrome 1; CD105; END; HHT1; CD105 antigen; ORW; ORW1; FLJ41744;
Gene ID: 2022
mRNA Refseq: NM_000118
Protein Refseq: NP_000109
MIM: 131195
UniProt ID: P17813
Chromosome Location: 9q34.11
Pathway: HIF-1-alpha transcription factor network, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem; TGF-beta Receptor Signaling Pathway, organism-specific biosystem;
Function: activin binding; galactose binding; glycosaminoglycan binding; glycosaminoglycan binding; protein binding; contributes_to protein binding; protein homodimerization activity; protein homodimerization activity; transforming growth factor beta binding; trans

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